Mathematical model of sepsis of newborn, whose parents lived in places of different environmental situation
Keywords:
neonatal sepsis, ecological risk coefficient, mathematical modelAbstract
Purpose — to create a mathematical model of newborns with neonatal sepsis whose parents lived in places with different environmental conditions with further improvement of sepsis management of newborns whose parents lived in places with unfavorable environmental conditions.
Materials and methods. We examined 260 newborns with neonatal sepsis, whose parents lived in different environmental conditions. The proposed environmental risk factor (CER) taking into account the environmental situation in the regional centers was a group-forming feature of a comprehensive assessment of the long-term burden on the body of parents of newborns of anthropogenic pollution of air, water and soil in the regions.
Results. The analysis of the relationship between the indicators of a comprehensive examination of patients with sepsis showed that there is a probable connection between the environmental situation of the parents of newborns, risk factors for neonatal sepsis and its clinical and laboratory manifestations. It is established that in the created mathematical model of severity of sepsis of newborns whose parents lived in places of the increased ecological risk, the main components of the main factors were KER, small gestational age, risk factors of early and late sepsis, indicators of metabolic and respiratory acidosis, the increased content of blood. -8 and multiorgan dysfunction, as well as the presence of apoptosis.
Conclusions. The mathematical model of neonatal sepsis, created by multifactor correlation analysis, indicates the presence of two phenotypes of neonatal sepsis, which are based on the ecological characteristics of the habitats of parents of sick children, which will further create a neonatal sepsis management algorithm.
The study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution indicated in the work. Informed consent of parents of children was obtained for the research.
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