Childhood mental developmental disorders: causes and possibilities of prevention

Authors

Keywords:

mental development disorders, children, diagnosis, treatment, rehabilitation

Abstract

Mental deficiency or mental retardation is not only a challenging ordeal for a child and their family, but also a problem for any country's health care system. The lack of common terminology and unified diagnostic approaches does not allow us to determine the real extent of the problem, but it is estimated that mental retardation is observed in about 1–3% of the world's population and prevails in low and middle income countries. Mental retardation can manifest in children of different ages; it can have different degrees of severity and different potential for correction efficiency, which makes timely diagnosis an important but also a challenging task. Approaches to identifying mental development disorders vary depending on the age of the child.
The aim is to familiarize a wide audience of doctors with the principles of diagnosis, possible medical intervention and rehabilitation of children with mental disorders.
The following main issues are discussed: common causes of impaired mental development; the influence of malnutrition on the development of mental retardation; diagnosis of mental development disorders in children of different ages; important elements of an objective examination in identifying impaired mental development; intelligence assessment with the IQ coefficient calculation; opportunities for prevention and correction of mental development disorders in children. Mental development retardation should be in the spotlight of attention of doctors of various specialties, taking into account the wide range of causes leading to it. General practitioners have a special role in issues of timely diagnosis of mental disorders, identification of possible causes, and creation of a survey plan. The prevention of forms of mental deficiency associated with malnutrition, insufficient parental attention to the upbringing of the child, and the influence of various environmental factors also depend on them. In many cases, mental retardation and general developmental disorders are easier to prevent than to treat.
No conflict of interest were declared by the authors.

References

American Association of Intellectual and Developmental Disabilities. (2016). Intellectual disability. URL: https://aaidd.org/intellectual-disability. Accessed July 7, 2016.

Behrooz HG, Tohidi M, Mehrabi Ya et al. (2011). Subclinical hypothyroidism in pregnancy: intellectual development of offspring. Thyroid. 21 (10): 1143—1147. https://doi.org/10.1089/thy.2011.0053; PMid:21943136 PMCid:PMC3179614

Bougma K et al. (2013). Iodine and Mental Development of Children 5 Years Old and Under: A Systematic Review and Meta-Analysis. Nutrients. 5: 1384—1416. https://doi.org/10.3390/nu6125770; PMCid:PMC4276997.

Braaten BE, Norman D. (2006). Intelligence (IQ) Testing. Pediatrics in Review November. 27 (11): 403—408. https://doi.org/10.1542/pir.27-11-403; PMid:17079505

Cerbone M, Bravaccio C, Capalbo D, Polizzi M, Wasniewska M, Cioffi D, Improda N, Valenzise M, Bruzzese D, De Luca F, Salerno M. (2011). Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur J Endocrinol. 164: 591—597. https://doi.org/10.1530/EJE-10-0979; PMid:21292920

Committee on Substance Abuse and Committee on Children with Disabilities. (2000). Fetal Alcohol Syndrome and Alcohol-Related Neurodevelopmental Disorders. Pediatrics. 106. 358. https://doi.org/10.1542/peds.106.2.358.

De Escobar GM, Obregon MJ, Escobar F. (2004). Del Rey Role of thyroid hormone during early brain development. European Journal of Endocrinology. 151: 25—37. https://doi.org/10.1530/eje.0.151u025; PMid:15554884

Ergur AT, Taner Y, Ata E, Melek E, Bakar EE, Sancak T. (2012). Neurocognitive functions in children and adolescents with subclinical hypothyroidism. J Clin Res Pediatr Endocrinol. 4: 21—24. https://doi.org/10.4274/Jcrpe.497; PMid:22394701 PMCid:PMC3316458

Julvez J, Alvarez-Pedrerol M, Rebagliato M, Murcia M, Forns J, Garcia-Esteban R, Lertxundi N, Espada M, Tardon A, Riano Galan I, Sunyer J. (2013). Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. Epidemiology. 24: 150—157. https://doi.org/10.1097/EDE.0b013e318276ccd3; PMid:23232616

Mamenko MYe. (2017). Prevention of iodine deficiency disorders: what should know and can do a pediatrician and general practitioner? (Clinical practice guideline). Sovremennaya pediatriya. 2(82): 8—16. https://doi.org/10.15574/SP.2017.82.8.

Maulik PK, Mascarenhas MN, Mathers DM, Dua T, Saxena S. (2011, Mar-Apr). Prevalence of Intellectual Disability: a Meta0Analysis of Population-Based Studies. Res Dev Disabil. 32 (2): 419—436. https://doi.org/10.1016/j.ridd.2010.12.018

PMid:21236634

Mishra S, Mishra AP. (2018). Approach to Neurodegenerative Disease in Children: A Short Review. Progressing Aspects in Pediatrics and Neonatology. 1 (5). PAPN. https://doi.org/10.32474/PAPN.2018.01.000121

Moeschler JB, Shevell M. (2014). Comprehensive Evaluation of the Child With Intellectual Disability or Global Developmental Delays. Pediatrics September. 134 (3): e903-e918. https://doi.org/10.1542/peds.2014-1839; PMid:25157020

MOZ Ukrainy. (2008). Klinichnyi protokol medychnoho dohliadu za zdorovoiu dytynoiu do 3 rokiv. Nakaz MOZ Ukrainy vid 20.03.2008 No. 149: 84.

Pedersen CB, Mors O, Bertelsen A et al. (2014). A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry. 71 (5): 573—581. https://doi.org/10.1001/jamapsychiatry.2014.16; PMid:24806211.

Puiu M, Dumitriu S, Chiritta-Emandi A, Gradinaru R, Arghirescu S. (2013, Jan 9). The Genetics of Mental Retardation, Genetic Disorders, Intech Open, doi: 10.5772/52964. URL: https://www.intechopen.com/books/genetic-disorders/the-genetics-of-mental-retardation. https://doi.org/10.5772/52964

Purugganan O. (2018, Jun). Intellectual Disabilities. Pediatrics in Review. 39 (6): 299—309. https://doi.org/10.1542/pir.2016-0116; PMid:29858292

Rare Disease UK. (2018). Living with a rare condition: the effect on mental health — Rare Disease UK. URL: www.raredisease.org.uk/our-work/living-with-a-rare-condition-the-effect-on-mental-health-2018/. Accessed October 19, 2018.

Raymond J, La Franchi SH. (2010). Fetal and neonatal thyroid function: review and summary of significant new findings. Curr Open Endocrinol Diabetes Obes. 17 (1): 1—7. https://doi.org/10.1097/MED.0b013e328333b0b2; PMid:19901830

World Heals Organization. (2020). Micronutrient deficiencies. URL: https://www.who.int/nutrition/topics/idd/en.

Zimmermann MB. (2009). Iodine Deficiency. Endocrine Reviews. 30 (4): 376—408. https://doi.org/10.1210/er.2009-0011; PMid:19460960