Vitamin d metabolism in children with stunted growth
Keywords:
vitamin D, growth, growth hormone, insulin-like growth factor 1, growth hormone deficiencyAbstract
Human growth is a complex interaction depending on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each developmental stage is growh hormone (GH) and its mediator, somatomedin, insulin-like growth factor 1 (IGF-1). Vitamin D is involved in the processes of bone growth and mineralization by regulating the metabolism of calcium and phosphorus. The article reviewed and analyzed clinical studies that show the relationship between vitamin D and the axis of GH/IGF-1 in the pediatric population. Vitamin D deficiency has been assessed in patients with GH deficiency, and a relationship between serum metabolites of vitamin D and IGF-1 has been identified. Based on the analysis of the literature, it can be assumed that in subjects suffering from somatotropic insufficiency, in most cases, vitamin D deficiency, which must be taken into account in therapy with recombinant growth hormone. Levels of GH and IGF-1 are more likely to be stabilized by additional treatment with vitamin D.References
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