The state of the cytokine profile in newborns with intrauterine infections
Keywords:intrauterine infection, interleukins, parameters of immunity
AbstractThe early diagnosis of infectious and inflammatory diseases in newborns remains relevant to date, and therefore, in recent years, of great interest is the study of the role of immunity indicators in the pathogenesis of infectious diseases in newborns.
Aim. To study the features of the cytokine profile in children of different gestational age, born with intrauterine infections.
Materials and methods. To assess the level of mediators of the immune response during intrauterine infections in newborns of different gestational age, the levels of IL-8, IL-10, TNFα were determined in the blood.
Results. The study of the characteristics of the immune status in newborn babies born with intrauterine infection showed that a change in the ratios of inflammatory mediators correlates with the severity of the infection process. The results obtained indicate a general tendency to increase the level of pro-inflammatory cytokines (IL-8, TNFα) in both full-term and premature babies with intrauterine infections. Changes in the level of IL-10 are of a different nature, so, in contrast to proinflammatory cytokines, the content of IL-10 in full-term and premature infants is reduced compared with children in the control group.
Conclusions. In newborns with different gestational ages of full-term and premature infants with intrauterine infections, there was an imbalance in the cytokine profile, which is confirmed by an increase in the level of pro-inflammatory cytokines and a decrease in the level of anti-inflammatory cytokine in comparison with uninfected children.
The study was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution. The informed consent of patients and parents of children (or their guardians) was obtained for the studies.
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