The state of the cytokine profile in newborns with intrauterine infections


  • A. A. Mammadova Scientific researches Institutes of Pediatrics named after K. Farajeva, Baku, Azerbaijan, Azerbaijan


intrauterine infection, interleukins, parameters of immunity


The early diagnosis of infectious and inflammatory diseases in newborns remains relevant to date, and therefore, in recent years, of great interest is the study of the role of immunity indicators in the pathogenesis of infectious diseases in newborns.
Aim. To study the features of the cytokine profile in children of different gestational age, born with intrauterine infections.
Materials and methods. To assess the level of mediators of the immune response during intrauterine infections in newborns of different gestational age, the levels of IL-8, IL-10, TNFα were determined in the blood.
Results. The study of the characteristics of the immune status in newborn babies born with intrauterine infection showed that a change in the ratios of inflammatory mediators correlates with the severity of the infection process. The results obtained indicate a general tendency to increase the level of pro-inflammatory cytokines (IL-8, TNFα) in both full-term and premature babies with intrauterine infections. Changes in the level of IL-10 are of a different nature, so, in contrast to proinflammatory cytokines, the content of IL-10 in full-term and premature infants is reduced compared with children in the control group.
Conclusions. In newborns with different gestational ages of full-term and premature infants with intrauterine infections, there was an imbalance in the cytokine profile, which is confirmed by an increase in the level of pro-inflammatory cytokines and a decrease in the level of anti-inflammatory cytokine in comparison with uninfected children.
The study was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution. The informed consent of patients and parents of children (or their guardians) was obtained for the studies.


Botvin'eva IA, Renge LV, Zorina VN, Zorina RM et al. (2013). Cytokine levels in maternal blood and umbical cord sera from women with symptoms of intrauterine infection. Medical Immunology. 15(3): 277—282.

Volodin NN, Degtyareva MV. (2001). Immunology of the perinatal period Pediatria. 4: 4—8.

Dolgikh TI, Belkova TN, Tirskaya YuI. (2014). Evaluation of cytokine regu;

lation in the diagnostic algorithm for intrauterine infections in newborns

from mothers at high risk. Cytokines and Inflammation.13;1: 47—50.

Novikova ON, Ushakova GA, Vavin GV. (2014). Immune response mediators of the mother and newborn in intrauterine infection. Gynecology, Obstetrics and Perinatology. 13;4: 74—77.

Rusakova LA. (2011). Modern approaches to the diagnosis of intrauterine infection of the fetus. Bulletin of RSMU. 2: 161.

Zinserling VA, Melnikova VF (2002). Perinatal infections: A practical guide. St. Petersburg: Albi: 352.

Pinninti SG, Ross SA, Shimamura M, Novak Z et al. (2015). Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection.Pediatr Infect Dis J.34: 536—537.; PMid:25876092 PMCid:PMC4400866

Sharma D, Shastri S, Farahbakhsh N, Sharma P. (2016). Intrauterine growth restriction — part 1. J Matern Fetal Neonatal Med. 29: 3977—3987.; PMid:26856409

Torgerson PR, Mastroiacovo P. (2013). The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ. 91: 501—508.; PMid:23825877 PMCid:PMC3699792

Yamamoto R, Ishii K, Shimada M, Hayashi S et al. (2013). Significance of maternal screening for toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus infection in cases of fetal growth restriction. J Obstet Gynaecol Res. 39: 653—657.; PMid:23107457



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