Assessing the psychomotor development using the denver screening test II in infants who have had jaundice in the neonatal period
Abstract
Material and methods. 86 children who have had jaundice in the neonatal period were examined and were divided into 2 groups depending on gestational age at the time of birth: Group I — full term (n=54), Group II — born prematurely (n=32). All examined at 3, 6, 9, 12 months were assessed for psychomotor development using the Denver screening test II. To study the influence the neonatal hyperbilirubinemia on hematoencephalic barrier (blood0brain barrier) permeability in all children in the dynamics of the neonatal period (1–3, 5–7, 21–28 days), neurospecific proteins — neurospecific enolase (NSE), glial fibrillary acidic protein (GFAP) and trophic brain factor (BDNF) were identified.Results and conclusions. The results of the study showed that 22.2% of full0term and 35.3% of prematurely born children who had hyperbilirubinemia in the neonatal period had a delay in development. In children with psychomotor retardation, both full0term and prematurely born, higher levels of neurospecific proteins were observed in the neonatal period compared with children with normal psychomotor development, which allows using these indicators as prediction criteria.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee (LEC) of an institution.
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