Кawasaki disease in a 7-year-old boy mimicking a peritonsillar abscess
DOI:
https://doi.org/10.15574/SP.2026.1(153).157162Keywords:
Kawasaki disease, coronary artery aneurysms, peritonsillar abscess, acetylsalicylic acid, intravenous immunoglobulin, children, echocardiography, vasculitis, feverAbstract
Aim - to analyze a clinical case of incomplete Kawasaki disease (KD) with atypical manifestations and to highlight the importance of early recognition in pediatric patients presenting with persistent fever unresponsive to antimicrobial therapy.
Clinical case. This report describes an atypical presentation of KD in a 7-year-old child manifesting as a presumed peritonsillar abscess, representing a rare otorhinolaryngological phenotype that significantly complicated the diagnostic process. A previously healthy boy was admitted with a 4-day history of high-grade fever, odynophagia, and painful cervical lymphadenopathy. Initial clinical assessment suggested a peritonsillar abscess; however, needle aspiration yielded no purulent discharge. Empirical antibiotic therapy failed to achieve clinical improvement. Magnetic resonance imaging excluded abscess formation and demonstrated inflammatory changes consistent with tonsillitis and cervical lymphadenopathy. By day 7 of illness, progressive thrombocytosis and bilateral non-exudative conjunctival injection were observed. Based on the constellation of clinical features (prolonged fever, mucocutaneous involvement, lymphadenopathy) and laboratory findings (elevated inflammatory markers, anemia, thrombocytosis), a diagnosis of incomplete KD was established in accordance with the American Heart Association guidelines. Treatment of intravenous immunoglobulin (IVIG) in combination with acetylsalicylic acid resulted in rapid defervescence and marked clinical improvement. Serial echocardiographic evaluations revealed no coronary artery abnormalities.
Conclusions. KD should be considered in the differential diagnosis of pediatric patients with fever lasting more than 5 days and presumed bacterial infections refractory to antibiotic therapy. Early recognition and timely initiation of IVIG therapy are critical for reducing the risk of coronary artery complications. Heightened awareness among clinicians, particularly in otorhinolaryngology and emergency settings, is essential.
The study was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent was obtained from the children's parents.
The authors declare no conflict of interest.
References
Bratincsak A, Reddy VD, Purohit PJ, Tremoulet AH, Molkara DP, Frazer JR et al. (2012). Coronary artery dilation in acute Kawasaki disease and acute illnesses associated with fever. Pediatr Infect Dis J. 31: 924-926. https://doi.org/10.1097/INF.0b013e31826252b3; PMid:22673140
Burns JC. (2024, Mar 1). The etiologies of Kawasaki disease. J Clin Invest. 134(5): e176938. https://doi.org/10.1172/JCI176938; PMid:38426498 PMCid:PMC10904046
Choi SH, Kim HJ. (2010). A case of Kawasaki disease with coexistence of a parapharyngeal abscess requiring incision and drainage. Korean J Pediatr. 53(9): 855-858. https://doi.org/10.3345/kjp.2010.53.9.855; PMid:21189972 PMCid:PMC3005218
Homicz MR, Carvalho D, Kearns DB, Edmonds J. (2000). An atypical presentation of Kawasaki disease resembling a retropharyngeal abscess. Int J Pediatr Otorhinolaryngol. 54(1): 45-49. https://doi.org/10.1016/S0165-5876(00)00337-2; PMid:10960696
Isidori C, Sebastiani L, Esposito S. (2019). A case of incomplete and atypical kawasaki disease presenting with retropharyngeal involvement. Int J Environ Res Public Health. 16(18): 3262. https://doi.org/10.3390/ijerph16183262; PMid:31491922 PMCid:PMC6765912
Kritsaneepaiboon S, Tanaanantarak P, Roymanee S, Lee EY. (2012). Atypical presentation of Kawasaki disease in young infants mimicking a retropharyngeal abscess. Emerg Radiol. 19(2): 159-163. https://doi.org/10.1007/s10140-011-1005-0; PMid:22134843
McCrindle BW, Rowley AH, Newburger JW, Newburger JW, Burns JC, Bolger AF et al. (2017). Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 135: e927. Epub 2017 Mar 29. doi: 10.1161/CIR.0000000000000484. Erratum in: Circulation. 2019 Jul 30; 140(5): e181-e184. PMID: 28356445. https://doi.org/10.1161/CIR.0000000000000703
MacHaira M, Tsolia M, Constantopoulos I, Garoufi A, Kaltsa M, Radiotis A et al. (2012). Incomplete Kawasaki disease with intermittent fever and retropharyngeal inflammation. Pediatric Infectious Disease Journal. 31(4): 417-418. https://doi.org/10.1097/INF.0b013e3182447a6c; PMid:22189530
Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC et al. (2004). Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 114: 1708-1733. https://doi.org/10.1542/peds.2004-2182; PMid:15574639
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Modern pediatrics. Ukraine

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The policy of the Journal “MODERN PEDIATRICS. UKRAINE” is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license (СС BY-NC).
Authors transfer the copyright to the Journal “MODERN PEDIATRICS. UKRAINE” when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.
Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.
The use of published materials for commercial purposes is strongly prohibited.