Clinical masks of celiac disease in children: examples from practice
DOI:
https://doi.org/10.15574/SP.2025.6(150).104109Keywords:
celiac disease, children, gluten intolerance, diagnosticsAbstract
Celiac disease is a chronic autoimmune disease, the basis of its pathogenesis is damage of the mucous membrane of the small intestine by gluten. The prevalence of celiac disease is steadily rising and occurs in both children and adults. Clinical manifestations of celiac disease can be typical, i.e. the development of diarrhea, steatorrhea, malabsorption, and atypical ones.
The aim: to deepen the knowledge of doctors about the polymorphism of clinical forms of celiac disease in children.
Clinical case. The article highlights three cases of atypical course of celiac disease and gluten-sensitive disease. Various clinical forms of gluten intolerance in children are shown, which were manifested by recurrent alopecia, persistent seborrhea, pronounced abdominal syndrome after taking a gluten-containing product in combination with rapid physical activity.
Conclusions. Іn addition to celiac disease, there are a number of that make their recognition complicated and delay their treatment. That is why timely clinical and laboratory diagnosis of gluten-sensitive diseases is important, and it allows us to recognize the disease on time, to prescribe treatment and thereby to optimize the prognosis.
The research was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
References
Bai JC. (2013, Feb). World Gastroenterology Organisation: Global Guidelines on Celiac Diseasе. Global recommendations of the World Gastroenterology Organization regarding celiac disease. J Clin Gastroenterol. 47(2): 121-126.
Belousova OYu. (2016). Hypersensitivity to gluten without celiac disease: an expert's comment. Health of Ukraine. Special issue "Pediatrics". 1(36): 25-28.
Belousova OYu. (2017, Sep). Diagnostic standards of gluten-dependent diseases: current trends. "Health of Ukraine" newspaper, thematic issue "Pediatrics". 3(42).
Brockow K, Kneissl D, Valentini L et al. (2015). Using a gluten oral food challenge protocol to improve diagnosis of wheat-dependent exercise-induced anaphylaxis. J Allergy Clin Immunol. 135(4): 977-984. Epub 2014 Sep 27. https://doi.org/10.1016/j.jaci.2014.08.024; PMid:25269870
Cianferoni A, Khullar K, Saltzman R et al. (2013). Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children. World Allergy Organ J. 6(1): 14. https://doi.org/10.1186/1939-4551-6-14; PMid:23965733 PMCid:PMC3765891
Cianferoni A, Muraro A. (2012). Food-induced anaphylaxis. Immunol Allergy Clin North Am. 32(1): 165-195. https://doi.org/10.1016/j.iac.2011.10.002; PMid:22244239 PMCid:PMC3440177
Drossman DA, Hasler WL. (2016). Rome IV - Functional GI Disorders: Disorders of Gut-Brain. Interaction. Gastroenterology. 150(6): 1257-1261. https://doi.org/10.1053/j.gastro.2016.03.035; PMid:27147121
Fasano A, Sapone A, Zevallos V, Schuppan D. (2015). Nonceliac gluten sensitivity. Gastroenterology. 148(6): 1195-1204. https://doi.org/10.1053/j.gastro.2014.12.049; PMid:25583468
Gubska OYu. (2014). Celiac disease. Clinic, diagnosis, treatment. Lecture. URL: https://celiac-ukraine.com/stati-o-tseliakii/tseliakiya-klinika-diagnostika-lechenie.
Husby S, Koletzko S, Korponay-Szabo IR et al. (2012.) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease. For the ESPGHAN Working Group on Coeliac Disease Diagnosis, on behalf of the ESPGHAN Gastroenterology committee. JPGN. 54(1): 136-160. https://doi.org/10.1097/MPG.0b013e31821a23d0; PMid:22197856
Kharchenko NV, Babaka OYa. (2017). Gastroenterology. A textbook in 2 volumes. Edited by N.V. Kharchenko, O.Ya Babaka. 2nd ed., revised, supplemented. Kirovohrad: Polium. 2: 432. illustrations, tables; 4 p. colour incl.
Ludvigsson J, Leffler D, Bai JC, Biagi F et al. (2012, Jan). The Oslo definitions for coeliac disease-related terms. Gut. 62(1): 43-52. Epub 2012 Feb 16. https://doi.org/10.1136/gutjnl-2011-301346; PMid:22345659 PMCid:PMC3440559
Ministry of Health of Ukraine. (2010). On approval of protocols for diagnosis and treatment of digestive organs in children. Order of the Ministry of Health of Ukraine dated 05/26/2010 N 438.
Naumova OO, Zabrodska LV, Kalynyuk VM. (2021). Anaphylaxis associated with physical exertion as a manifestation of food allergy to wheat. Clinical immunology. Allergology. Immunology. 3(132): 25-31.
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