Characteristics of hemodynamics in cerebral vessels in non-traumatic intracranial hemorrhages
DOI:
https://doi.org/10.15574/SP.2025.6(150).4045Keywords:
non-traumatic hemorrhages, intracranial hemorrhages, hemodynamics, cerebral vessels, newbornAbstract
Aim - to characterize cerebral hemodynamic disturbances in newborns with intracranial non-traumatic hemorrhages (INTH) depending on the severity of the condition, in order to optimize treatment strategies for perinatal pathologies.
Materials and methods. The study was conducted at the Azerbaijan Republician Perinatal Center. Neurosonography was performed on 800 full-term newborns within the first 24 hours of life, and on 192 preterm newborns depending on their condition: 50 infants on day 1, 99 - on day 3, 27 - on day 5, and 20 - on day 7. Using this method, the maximal systolic velocity (Vmax), minimal diastolic velocity (Vmin), and resistance index (RI) were measured. Statistical analysis of the obtained results was performed in Excel: the mean values and standard errors were calculated.
Results. Ventricular dilatation was recorded in 6 infants. In preterm infants (gestational age ≤36 weeks) with and without INTH, the Vmax in the anterior cerebral artery was 0.27±0.005 and 0.30±0.006 m/s, the Vmin was 0.007±0.001 and 0.009±0.001 m/s, and the mean flow velocity was 0.18±0.005 and 0.20±0.004 m/s, respectively, demonstrating statistically significant differences between the groups. Hemodynamics were comparatively slower in infants with INTH. The Vmin in the anterior cerebral artery differed significantly between preterm and full-term infants without INTH (0.09±0.01 and 0.10±0.02 m/s), with lower values in preterm infants. A similar pattern was found when comparing preterm and full-term infants with INTH (0.07±0.001 and 0.08±0.002 m/s). The mean flow velocity in the anterior cerebral artery differed significantly between preterm infants with INTH (0.18±0.005 m/s) and without INTH (0.20±0.004 m/s). Comparable statistically significant differences were also observed between full-term infants with INTH (0.19±0.005 m/s) and without INTH (0.20±0.004 m/s).
Conclusion. In newborns with INTH, cerebral hemodynamics slow down proportionally to the severity of hemorrhage. The more severe the hemorrhage, the greater the hemodynamic delay. Therefore, large-scale neurosonographic screening of newborns in perinatal centers is essential.
The study complied with the principles of the Declaration of Helsinki and was approved by the institutional Ethics Committee. The informed consent was obtained from the patients prior to participation.
The author declares no conflict of interest.
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