Features of the neurological status of newborns from mothers with parvovirus B19 infection
DOI:
https://doi.org/10.15574/SP.2024.7(143).6267Keywords:
рarvovirus B19, non-immune fetal hydrops, intrauterine transfusion, neurological disorders, fetal anemiaAbstract
To date, the issue of parvovirus B19 (B19V) infection in pregnant women and its impact on the fetus remains quite relevant. B19V is one of the causes of perinatal pathology, particularly non-immune fetal hydrops (NIFH), which can lead to intrauterine anemia, heart failure, and fetal death.
Aim - to investigate the neurological status of newborns who underwent intrauterine treatment for NIFH caused by B19V infection.
Materials and methods. A retrospective analysis of the medical histories of 32 pregnancies complicated by NIFH due to parvovirus B19 was conducted over the period 2022-2024 at the Perinatal Center in Kyiv. Intrauterine erythrocyte transfusions were performed on 11 fetuses with severe anemia. Neurological status was assessed using the HINE scale at 3 and 6 months of age.
Results. Survival after treatment reached 72.7%, while mortality without treatment was 100%. A favorable prognosis for future neurological disorders was noted in 62.5% of the children, while 37.5% showed a risk of impairments.
Conclusions. Intrauterine erythrocyte transfusions are effective in treating fetal anemia caused by B19V infection. However, neurological disorders remain possible, requiring continued follow-up of children after treatment.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.
The authors declare no conflict of interest.
References
Alsamarai AM, Hassan HM, Alsamarai MA, Aljumaili ZK. (2021). Parvovirus B19 Seroprevalence in Women with Bad Obstetric History in Kirkuk. Antiinflamm Antiallergy Agents Med. Chem. 20: 359-366. https://doi.org/10.2174/1871523020666210727142351; PMid:34315400
Bondarenko NP, Lakatosh VP, Lakatosh PV. (2018). Neimunnavodianka ploda, indukovana parvovirusom V19-diahnostyka pid chas vahitnosti ta perynatalni naslidky. Neonatolohiia, khirurhiia ta perynatalna medytsyna. 8 (1): 59-64.
Bondarenko NP, Lakatosh VP, Lakatosh PV, Poladych IV. (2015). Diahnostychna tsinnist kombinovanoho metodu imunofermentnoho analizu ta polimeraznoi lantsiuhovoi reaktsii dlia vyiavlennia vnutrishnoutrobnoho infikuvannia ploda parvovirusom V19. Lik. Sprava - Vracheb. delo. 3-4: 121-128. https://doi.org/10.31640/LS-2015-(3-4)-20
Dittmer FP, Guimarães CM, Peixoto AB, Pontes KFM, Bonasoni MP et al. (2024, Jan 26). Parvovirus B19 Infection and Pregnancy: Review of the Current Knowledge. J Pers Med. 14(2): 139. https://doi.org/10.3390/jpm14020139; PMid:38392573 PMCid:PMC10890458
Esmel-Vilomara R, Dolader P, Izquierdo-Blasco J, Balcells J, Sorlí M, Escudero F et al. (2022, May). Parvovirus B19 myocarditis in children: a diagnostic and therapeutic approach. Eur J Pediatr. 181(5): 2045-2053. Epub 2022 Feb 9. https://doi.org/10.1007/s00431-022-04406-x; PMid:35138467
Feng S, Zeng D, Zheng J, Zhao D. (2020, Oct). New Insights of Human Parvovirus B19 in Modulating Erythroid Progenitor Cell Differentiation. Viral Immunol. 33(8): 539-549. Epub 2020 May 15. https://doi.org/10.1089/vim.2020.0013; PMid:32412895
Grubman O, Hussain FN, Nelson Z, Brustman L. (2019). Maternal Parvovirus B19 Infection Causing First- Trimester Increased Nuchal Translucency and Fetal Hydrops. Case Rep Obstet Gynecol. 2019: 3259760. URL: https://downloads.hindawi.com/journals/criog/2019/3259760.pdf. https://doi.org/10.1155/2019/3259760; PMid:31360565 PMCid:PMC6642751
Guo J, Wang Y, Zhang M, Zheng H, Zang Q, Huang P et al. (2022). Human parvovirus B19 infection in hospitalized patients suspected of infection with pathogenic microorganism. Front Cell Infect Microbiol. 12: 1083839. URL: https://www.frontiersin.org/articles/10.3389/fcimb.2022.1083839/full. https://doi.org/10.3389/fcimb.2022.1083839; PMid:36619750 PMCid:PMC9812433
Hellmund A, Geipel A, Berg C, Bald R, Gembruch U. (2018). Early Intrauterine Transfusion in Fetuses with Severe Anemia Caused by Parvovirus B19 Infection. Fetal Diagn Ther. 43(2): 129-137. https://doi.org/10.1159/000477208; PMid:28633140
Monteiro VS, Baía-da-Silva DC, Silva VA, Pivoto João GA, Marinho EPM, Cubas-Vega NC et al. (2021, Aug 27). Neurological Manifestations Associated with Parvovirus B19 Infection in Immunocompetent Children: Case Series and Systematic Review. J TropPediatr. 67(4): fmab078. https://doi.org/10.1093/tropej/fmab078; PMid:34545404
Moosazadeh M, Alimohammadi M, Mousavi T. (2023). Seroprevalence and geographical distribution of parvovirus B19 antibodies in pregnant women: A-metaanalysis. J. Immunoass. Immunochem. 44: 103-116. https://doi.org/10.1080/15321819.2023.2167520; PMid:36661768
Voordouw B, Rockx B, Jaenisch T, Fraaij P, Mayaud P et al. (2019). Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays. Clin. Microbiol. Rev. 33: e00130-18. https://doi.org/10.1128/CMR.00130-18; PMid:31826871 PMCid:PMC6927310
Xiong YQ, Tan J, Liu YM, He Q, Li L, Zou K, Sun X. (2019). The risk of maternal parvovirus B19 infection during pregnancy on fetal loss and fetal hydrops: A systematic review and meta-analysis. J. Clin. Virol. 114: 12-20. https://doi.org/10.1016/j.jcv.2019.03.004; PMid:30897374
Watanabe T, Kawashima H. (2015, Nov 8). Acute encephalitis and encephalopathy associated with human parvovirus B19 infection in children. World J Clin Pediatr. 4(4): 126-34. https://doi.org/10.5409/wjcp.v4.i4.126; PMid:26566485 PMCid:PMC4637803
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