Determination of the antimicrobial action of "Coldisept nanoSilver nasal spray" and "Coldisept nanoSilver throat spray"
DOI:
https://doi.org/10.15574/SP.2024.5(141).1115Keywords:
Coldisept nanoSilver nasal spray, Coldisept nanoSilver throat spray, nanosilver, physicochemical properties, bacteria, virusesAbstract
Acute respiratory diseases are caused by viruses and bacterial flora. Treatment of acute pharyngitis as the main clinical form of respiratory diseases is mainly local.
The aim is to study the antimicrobial effect of "Coldisept nanoSilver nasal spray" (manufacturer "ARKONA", Poland) and "Coldisept nanoSilver throat spray" (manufacturer "ARKONA", Poland) on clinical isolates of microorganisms Streptococcus pneumoniae, Staphylococcus aureus, Moraxella catarrhalis, Pseudomonas aeruginosa, Haemophilus influenza (hospital strains) and Candida albicans isolated from the nose and oropharynx of patients.
Materials and methods. Antimicrobial activity was evaluated after 5, 10 and 20 minutes of action of one dose of "Coldisept nanoSilver nasal spray" and "Coldisept nanoSilver throat spray" on microorganisms. Bactericidal and fungicidal effect (inhibition of the growth of cells of microorganisms) is expressed as a percentage.
Results. Koldisept nanoSilver nasal spray shows an antimicrobial effect on clinical isolates after 20 minutes: 79.6% - on Streptococcus pneumonia, 77.7% - on Moraxella catarrhalis, 44.0% - on Haemophilus influenza; and fungicidal effect (76.0%) on Candida albicans. Antimicrobial activity of Coldicept nanoSilver nasal spray against the hospital strain of Pseudomonas aeruginosa and Staphylococcus aureus was not detected. Coldisept nanoSilver throat spray shows 100% antimicrobial activity after 5 minutes against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, 100% antimicrobial activity after 20 minutes against clinical isolates of Streptococcus pyogenes, 75% fungicidal activity against Candida albicans strains through 20 min. A low antimicrobial effect of Coldisept nanoSilver throat spray against the hospital strain of Staphylococcus aureus, which is resistant to most antibiotics, was revealed.
Conclusions. The results obtained in the study of the antimicrobial action of the Coldisept nanoSilver nasal spray and the Coldisept nanoSilver throat spray on clinical isolates of microorganisms will contribute to a more rational prescription of these drugs in clinical practice.
The authors declare no conflict of interest.
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