Specifics of clinical manifestations of post-COVID-19 syndrome in children
DOI:
https://doi.org/10.15574/SP.2024.140.48Keywords:
children, post-COVID-19 syndrome, structure of post-COVID-19 syndromeAbstract
Coronavirus disease 2019 (COVID-19) and its long-term consequences have a significant negative impact on the lives of people around the world. The long-term consequences of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are known as the post-COVID-19 syndrome, the symptoms of which can persist for more than 12 weeks after the onset of the disease. Despite the measures already taken to control and combat the disease, the problem of establishing the structure of post-COVID-19 syndrome, especially in children, remains an important global problem for society.
Aim - to determine the data on the structure of the incidence of children with post-COVID-19 syndrome.
Materials and methods. We examined 505 children under 18 years of age with post-COVID-19 syndrome who were inpatients during January-July 2023. The source of information was the medical record of an inpatient (Form 003/O). The study was conducted by randomization. All sick children underwent a comprehensive clinical and laboratory examination in accordance with standard, generally accepted methods of clinical, laboratory and instrumental examination in pediatrics. Statistical processing was performed in the EZR program package (R-statistics).
Results. It was established that in children with post-COVID-19 syndrome, the smallest number were children under 3 years old (12.87%), and the largest number were children from 12 to 18 years old (31.69%). In children with post-COVID-19 syndrome, the most commonly affected sensory (80.20%) and nervous (78.61%) systems were noted.
Conclusions. The lesions of the nervous and sensory systems in children with post-COVID-19 syndrome are explained by the comorbidity of SARS-CoV-2 tropism to these systems and a sharp deterioration in the socioeconomic and psycho-emotional state of children with post-COVID-19 syndrome. The distribution of the examined children by gender and age simultaneously revealed a progressive increase in the frequency of male children with post-COVID-19 syndrome with increasing age. Identification of a combination of these factors in children may increase pediatricians' alertness to the occurrence of post-COVID-19 syndrome in children and will facilitate timely correction and diagnosis of post-COVID-19 syndrome.
The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of all the institutions mentioned in the work. Informed consent of parents and children was obtained for the study.
The authors declare no conflict of interest.
References
Anastassopoulou C, Gkizarioti Z, Patrinos GP, Tsakris A. (2020). Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. Human Genomics. 14(1): 40. https://doi.org/10.1186/s40246-020-00290-4; PMid:33092637 PMCid:PMC7578581
Cappadona C, Rimoldi V, Paraboschi EM, Asselta R. (2023). Genetic susceptibility to severe COVID-19. Infection, Genetics and Evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 110: 105426. https://doi.org/10.1016/j.meegid.2023.105426; PMid:36934789 PMCid:PMC10022467
Chernyshova LI. (2020). Koronavirusna infektsiia (lektsiia). Aktualna infektolohiia. 8(2): 6-9.
Davis HE, McCorkell L, Vogel JM, Topol EJ. (2023). Author Correction: Long COVID: major findings, mechanisms and recommendations. Nature Reviews Microbiology. 21(6): 408. https://doi.org/10.1038/s41579-023-00896-0; PMid:37069455 PMCid:PMC10408714
Felsenstein S, Hedrich CM. (2020). COVID-19 in children and young people. The Lancet. Rheumatology. 2(9): e514-e516. https://doi.org/10.1016/S2665-9913(20)30212-5; PMid:32838308
Hajeer A, Jawdat D, Massadeh S, Aljawini N, Abedalthagafi MS, Arabi YM, Alaamery M. (2022). Association of KIR gene polymorphisms with COVID-19 disease. Clinical Immunology (Orlando, Fla.). 234: 108911. https://doi.org/10.1016/j.clim.2021.108911; PMid:34929414 PMCid:PMC8683215
Hurianov VH, Liakh YuIe, Parii VD, Korotkyi OV, Chalyi OV. (2018). Posibnyk z biostatystyky. Analiz rezultativ medychnykh doslidzhen u paketi EZR (R-statistics): dlia mahistriv, interniv, klinichnykh ordynatoriv ta aspirantiv haluzi znan "Okhorona zdorovia". Kyiv: Vistka: 206.
Klomjit N, Zand L, Cornell LD, Alexander MP. (2023). COVID-19 and Glomerular Diseases. Kidney International Reports. 8(6): 1137-1150. https://doi.org/10.1016/j.ekir.2023.03.016; PMid:37274308 PMCid:PMC10041821
Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A et al. (2020). SARS-COV-2 infection in children and newborns: a systematic review. European Journal of Pediatrics. 179(7): 1029-1046. https://doi.org/10.1007/s00431-020-03684-7; PMid:32424745 PMCid:PMC7234446
Littera R, Chessa L, Deidda S, Angioni G, Campagna M, Lai S et al. (2021). Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection. PloS One. 16(8): e0255608. https://doi.org/10.1371/journal.pone.0255608; PMid:34352002 PMCid:PMC8341547
Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, Perelman C, Sepulveda R, Rebolledo PA et al. (2022). Long-COVID in children and adolescents: a systematic review and meta-analyses. Scientific Reports. 12(1): 9950. https://doi.org/10.1038/s41598-022-13495-5; PMid:35739136 PMCid:PMC9226045
Ma L, Mazidi M, Li K, Li Y, Chen S, Kirwan R et al. (2021). Prevalence of mental health problems among children and adolescents during the COVID-19 pandemic: A systematic review and meta-analysis. Journal of Affective Disorders. 293: 78-89. https://doi.org/10.1016/j.jad.2021.06.021; PMid:34174475 PMCid:PMC9711885
Murillo-Zamora E, Aguilar-Sollano F, Delgado-Enciso I, Hernandez-Suarez CM. (2020). Predictors of laboratory-positive COVID-19 in children and teenagers. Public Health. 189: 153-157. https://doi.org/10.1016/j.puhe.2020.10.012; PMid:33246302 PMCid:PMC7584439
Ng KW, Faulkner N, Cornish GH, Rosa A, Harvey R, Hussain S et al. (2020). Preexisting and de novo humoral immunity to SARS-CoV-2 in humans. Science (New York, N.Y.). 370(6522): 1339-1343. https://doi.org/10.1126/science.abe1107; PMid:33159009 PMCid:PMC7857411
Nikolopoulou GB, Maltezou HC. (2022). COVID-19 in Children: Where do we Stand? Archives of Medical Research. 53(1): 1-8. https://doi.org/10.1016/j.arcmed.2021.07.002; PMid:34311990 PMCid:PMC8257427
Piazza M, Di Cicco M, Pecoraro L, Ghezzi M, Peroni D, Comberiati P. (2022). Long COVID-19 in Children: From the Pathogenesis to the Biologically Plausible Roots of the Syndrome. Biomolecules. 12(4): 556. https://doi.org/10.3390/biom12040556; PMid:35454144 PMCid:PMC9024951
Polushkin PM. (2015).Posibnyk do vyvchennia kursu «Vikova fiziolohiia ta valeolohiia liudyny». D.: DNU: 138.
Riggioni C, Comberiati P, Giovannini M, Agache I, Akdis M, Alves-Correia M et al. (2020). A compendium answering 150 questions on COVID-19 and SARS-CoV-2. Allergy. 75(10): 2503-2541. https://doi.org/10.1111/all.14449; PMid:32535955 PMCid:PMC7323196
Tang S, Xiang M, Cheung T, Xiang YT. (2021). Mental health and its correlates among children and adolescents during COVID-19 school closure: The importance of parent-child discussion. Journal of Affective Disorders. 279: 353-360. https://doi.org/10.1016/j.jad.2020.10.016; PMid:33099049 PMCid:PMC7550131
Tian D, Sun Y, Xu H, Ye Q. (2022). The emergence and epidemic characteristics of the highly mutated SARS-CoV-2 Omicron variant. Journal of Medical Virology. 94(6): 2376-2383. https://doi.org/10.1002/jmv.27643; PMid:35118687 PMCid:PMC9015498
Viner RM, Ward JL, Hudson LD, Ashe M, Patel SV, Hargreaves D, Whittaker E. (2020). Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents. Archives of Disease in Childhood: archdischild-2020-320972. https://doi.org/10.1136/archdischild-2020-320972; PMid:33334728
Yong SJ. (2021). Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infectious Diseases (London, England). 53(10): 737-754. https://doi.org/10.1080/23744235.2021.1924397; PMid:34024217 PMCid:PMC8146298
Zhang JJ, Dong X, Liu GH, Gao YD. (2023). Risk and Protective Factors for COVID-19 Morbidity, Severity, and Mortality. Clinical Reviews in Allergy &Immunology. 64(1): 90-107. https://doi.org/10.1007/s12016-022-08921-5; PMid:35044620 PMCid:PMC8767775
Zimmermann P, Pittet LF, Curtis N. (2021). How Common is Long COVID in Children and Adolescents? The Pediatric Infectious Disease Journal. 40(12): e482-e487. https://doi.org/10.1097/INF.0000000000003328; PMid:34870392 PMCid:PMC8575095
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