Acute respiratory viral infections and influenza in children: before, during, after the COVID-19 pandemic

Authors

DOI:

https://doi.org/10.15574/SP.2024.140.23

Keywords:

children, influenza, acute respiratory viral infections, COVID-19

Abstract

The group of acute respiratory viral infections (ARVI) is one of the numerous and leading infectious viral diseases that can occur at any time of the year, recur, have a severe course and even be fatal.

The aim is to analyze the SARS/influenza problem in children in the period before, during and after the COVID-19 pandemic based on official statistics.

Materials and methods. The incidence rate of illness for the period 2010-2023 was analyzed using the database of official reports of: the Public Health Center of the Ministry of Health of Ukraine; WHO and USA Centers for Disease Prevention and Control.

Results. In the period before the COVID-19 pandemic, high seasonal intensity of influenza was noted in the periods of 2014-2015, 2017-2018, 2019-2020, caused by viruses A/H3N3, A/H3N2, A/H1N1 pdm09 and B, respectively . In terms of age, the main group consisted of children under 5 years of age. In all periods of 2010-2020, children made up the vast majority of flu patients. It is important that the 2019-2020 season, which coincided with an increase in the level of SARS-CoV-2 diseases, was also marked by a moderately high intensity of influenza and a predominance of children among the sick. In subsequent seasons, the incidence of influenza was lower. After overcoming the pandemic, the incidence rate of influenza exceeded the baseline in 23 of the 30 countries of the European region.

Conclusions. In the period before and after the COVID-19 pandemic, influenza remains the leading SARS in the world. The decrease in the number of influenza cases during the pandemic is due to a group of factors: the conditions of quarantine restrictions due to the appearance of the SARS-CoV-2 virus, active vaccination, increased public attention to this problem. In all periods (2010-2023), a regularity was noted regarding the age structure of patients with influenza - children prevailed; among the latter, the greatest threat is a severe or unfavorable course. The overcoming of the COVID-19 pandemic in the world determined the further increase in the incidence of influenza in the structure of SARS, which requires improving the awareness of parents about this pathology and the possible serious consequences due to increase adherence to the introduction of an appropriate level of specific and non-specific prevention.

The authors declare no conflict of interest.

References

Antypkin YG, Lapshyn VF, Umanets TR et al. (2023). Analysis of the COVID-19 prevalence among children in Ukraine during the first year of the pandemic .Child's Health. 18(1): 1-5. https://doi.org/10.22141/2224-0551.18.1.2023.1551

CDC. (2023). Past Flu Seasons. URL: https://www.cdc.gov/flu/season/past-flu-seasons.

Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases. (2024). Flu and Children at Higher Risk. URL: https://www.cdc.gov/flu/highrisk/children.htm.

Committee on infectious diseases. (2023). Recommendations for Prevention and Control of Influenza in Children, 2023-2024. Pediatrics. 152(4): e2023063772. https://doi.org/10.1542/peds.2023-063773; PMid:37641884

ECDC. (2024). Communicable disease threats report, 21-27 January 2024, week. Surveillance and monitoring. URL: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-21-27-january-2024-week-4.

Flerlage T, Boyd D.F, Meliopoulos V et al. (2021). Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract. Nat Rev Microbiol. 19: 425-441. https://doi.org/10.1038/s41579-021-00542-7; PMid:33824495 PMCid:PMC8023351

Haddadin Z, Schuster JE, Spieker AJ et al. (2021, Aug). Acute Respiratory Illnesses in Children in the SARS-COV-2 Pandemic: Prospective Multicenter Study Pediatrics. 148(2): e2021051462. https://doi.org/10.1542/peds.2021-051462; PMid:33986150 PMCid:PMC8338906

Huang C, Huang L, Wang Y et al. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 397: 220-232. https://doi.org/10.1016/S0140-6736(20)32656-8; PMid:33428867

Kandeel A, Fahim M, Deghedy O, Roshdy WH et al. (2023, Jun 5).Resurgence of influenza and respiratory syncytial virus in Egypt following two years of decline during the COVID-19 pandemic: outpatient clinic survey of infants and children, October 2022. BMC Public Health. 23(1): 1067. https://doi.org/10.1186/s12889-023-15880-9; PMid:37277781 PMCid:PMC10240446

Keeler SP, Agapov EV,Hinojosa ME et al. (2018). Influenza a virus infection causes chronic lung disease linked to sites of active viral RNA remnants. J. Immunol. 201: 2354-2368. https://doi.org/10.4049/jimmunol.1800671; PMid:30209189 PMCid:PMC6179922

Li Y, Wang X, Blau DM, Caballero MT, Feikin DR. (2022). Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 28; 399(10340): 2047-2064. https://doi.org/10.1016/S0140-6736(22)00478-0; PMid:35598608

Mettelman RC, Thomas PG. (2020). Human susceptibility to influenza infection and severe disease. Cold Spring Harb. Perspect. Med. 11(5): a038711. https://doi.org/10.1101/cshperspect.a038711; PMid:31964647 PMCid:PMC8091954

Munoz FM, Edwards MS. (2023). Seasonal influenza in children: Clinical features and diagnosis. URL: https://www.uptodate.com/contents/seasonal-influenza-in-children-clinical-features-and-diagnosis.

National Immunization Portal. (2023). Flu. URL: https://vaccine.org.ua/infections/gryp/.

Schober T, Wong K, DeLisle G et al. (2024). Clinical Outcomes of Rapid Respiratory Virus Testing in Emergency Departments. A Systematic Review and Meta-Analysis. JAMA Intern Med. Published online March 4. https://doi.org/10.1001/jamainternmed.2024.0037; PMid:38436951

Smith M, Honce R, Schultz-Cherry S. (2020). Metabolic syndrome and viral pathogenesis: lessons from influenza and coronaviruses. J. Virol. 94: e00665-20. https://doi.org/10.1128/JVI.00665-20; PMid:32661141 PMCid:PMC7459568

Ternopil Regional Center for Disease Control and Prevention. (2024). We inform you about the results of monitoring for influenza, SARS and COVID-19 as of February 5, 2024. URL: https://ockph.te.ua/index.php/node/3633

Tokars JI, Olsen SJ, Reed C. (2018). Seasonal Incidence of Symptomatic Influenza in the United States.Clinical Infectious Diseases. 66; 10: 1511-1518. https://doi.org/10.1093/cid/cix1060; PMid:29206909 PMCid:PMC5934309

Tsentr hromadskoho zdorov'ia MOZ Ukrainy. (2024). Influenza and SARS in Ukraine. Information bulletin. URL:https://phc.org.ua/kontrol-zakhvoryuvan/inshi-infekciyni-zakhvoryuvannya/zakhvoryuvanist-na-grip-ta-grvi-v-ukraini.

Tsentr hromadskoho zdorov'ia MOZ Ukrainy. (2024). Influenza and SARS in Ukraine. Information bulletin 4 week (22-28.01.2024). URL: https://phc.org.ua/kontrol-zakhvoryuvan/inshi-infekciyni-zakhvoryuvannya/zakhvoryuvanist-na-grip-ta-grvi-v-ukraini.

Ukrinform. (2023). WHO canceled the pandemic status of COVID-19. URL: https://www.ukrinform.ua/rubric-society/3705279-vooz-skasuvala-status-pandemii-covid19.html.

Uyeki TM , Bernstein HH, Bradley JS et al. (2019). Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza. Clin. Infect. Dis. 68: 895-902. https://doi.org/10.1093/cid/ciy874; PMid:30834445 PMCid:PMC6769232

Watanabe S, Hoshina T, Kojiro M et al. (2021). The recent characteristics of influenza-related hospitalization in Japanese children. Eur J Clin Microbiol Infect Dis. 40: 2011-2015. https://doi.org/10.1007/s10096-021-04208-3; PMid:33661411

Zhu G, Xu D, Zhang Y et al. (2021). Epidemiological characteristics of four common respiratory viral infections in children. Virol J. 18: 10. https://doi.org/10.1186/s12985-020-01475-y; PMid:33407659 PMCid:PMC7787583

Published

2024-05-28

Issue

Section

Original articles