The course of the post-vaccination period when using combined vaccines from different manufacturers during one vaccination cycle




vaccine, immunization, post-vaccination reactions, adherence, contraindications to vaccination, hexavalent vaccines, age-appropriate vaccination, combined vaccines, vaccine against diseases caused by Haemophilus influenzae type b, vaccine against pertussis, vaccine against diphtheria, vaccine against tetanus, vaccine against poliomyelitis, vaccine against hepatitis B, vaccine with a two-component pertussis component, vaccine with a three-component pertussis component


Purpose - to evaluate the postvaccination period when using 6-valent vaccines against pertussis, diphtheria, tetanus, poliomyelitis, hepatitis B and infections caused by Haemophilus influenzae type b from different manufacturers within the same vaccine cycle.

Materials and methods. The study was conducted on the basis of a private health care facility that provides outpatient admission, management, monitoring, and vaccination of children and adults. For the period from January 2020 to October 2023, we analyzed the records in the preventive vaccination registers, which were recorded the next day during routine monitoring of the child's condition after immunization. For the analysis, 343 children were selected and divided into 5 groups depending on the combination of doses of different hexavalent vaccines during the vaccine cycle (3 doses at 28-day intervals) and the first revaccination (one dose at 12-month intervals from the third dose).

Results. In all groups of subjects, most children had no complaints during the postvaccination period. The combination of 6-valent vaccines from different manufacturers was not accompanied by an increase in postvaccination reactions, on the contrary, a tendency to their decrease was noted. Some differences were observed when comparing post-vaccination reactions when using all 4 doses of the 3-component pertussis vaccine and the 2-component pertussis vaccine. Thus, vaccination with a 3-component pertussis component, in 32% was accompanied by a fever up to 38.5°C, and in only 15.38% in vaccine with a 2-component pertussis component, differences were not significant (p>0.05).

Conclusions. In heterologous immunization against pertussis, diphtheria, tetanus, poliomyelitis, hepatitis B and infections caused by Haemophilus influenzae type b with vaccines from different manufacturers with a 2- and 3-component pertussis component, the spectrum and percentage of post-vaccination reactions practically do not differ. Thus, the use of combinations of doses of different 6-valent vaccines is justified, which is especially relevant in the conditions of interruptions in the supply of vaccines and vaccination of children in various medical institutions during migration in war conditions, when there is a risk of delay in the introduction of the next dose of the vaccine and violation of the intervals between vaccinations.

The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.

No conflict of interests was declared by the authors.

Author Biographies

A.M. Pugach, Shupyk National Healthcare University of Ukraine, Kyiv

Medical Centre “Dobrodiy”, Kyiv, Ukraine

A.V. Bondarenko, Shupyk National Healthcare University of Ukraine, Kyiv

International European University, Kyiv, Ukraine


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