The frequency of anxiety-depressive syndrome in children with inflammatory bowel diseases
DOI:
https://doi.org/10.15574/SP.2024.137.101Keywords:
children, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, anxiety-depressive syndromeAbstract
Inflammatory bowel diseases (IBD) have been spreading rapidly in industrialized countries since the beginning of the 21st century.
Purpose - to determine the frequency of symptoms of anxiety and depression in children with IBD, in order to optimize treatment.
Materials and methods. 18 patients aged 10-17 years were surveyed: 10 people with ulcerative colitis (UC) and 8 people with Crohn’s disease (CD), symptoms of anxiety and depression were studied using PHQ-2, PHQ-9 questionnaires (Patient Health Questionnaire) and GAD-7 (Generalized Anxiety Disorder). The obtained results were analyzed using SPSS 26.0 programs. The odds ratio (OR) was considered significant if the 95% confidence interval (CI) did not include 1. The difference in samples was considered significant at p<0.05.
Results. Of the 18 patients who were surveyed using the PHQ-2 questionnaire, 13 (72.2%) were screened for further investigation using the PHQ-9 questionnaire. The prevalence of anxiety symptoms was 55.5% (95% CI: 38.3-66.5), depressive symptoms - 34.8% (95% CI: 21.4-45.8). Patients with CD had higher odds of anxiety symptoms (OR: 1.2, 95% CI: 1.1-3.6) and depressive symptoms (OR: 1.3, 95% CI: 1.1-1.7) than children with UC. There were differences in the severity of anxiety and depression in different pathological conditions (IBD: p<0.01; UC: p<0.05; CD: p=0.05). The frequency of symptoms of anxiety or depression was higher in patients with active IBD than in children with inactive disease (100% and 33.3% and 100% and 45.8%, respectively). Minimal (0-4 points) and mild (5-9) degrees of anxiety and depression prevailed.
Conclusions. The frequency of detection of symptoms of anxiety and depression in children with CD and UC in the active stage of the disease is 55.5% and 34.8%, respectively, with a predominance of minimal (0-4 points) and mild (5-9) degrees. Patients with CD are higher odds of anxiety and depression symptoms than children with UC.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
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