Structure of sensitization to fish and seafood in children
DOI:
https://doi.org/10.15574/SP.2024.137.14Keywords:
food allergy, respiratory allergy, allergy to fish and seafood, clinic, anaphylaxis, structure of sensitization, specific IgE, parvalbumin, tropomyosin, childrenAbstract
In recent years, about 4% of children and 1% of adults in the world have suffered from food allergies to fish and seafood. About 40% of children have a high level of threat of systemic reactions. Literature data on the prevalence of FA on fish and seafood in the world are summarized, the principles of modern diagnostics are defined, taking into account the possibilities of molecular component diagnostics of fish and seafood allergen molecules.
Purpose – To analyze the prevalence of allergies to fish and seafood in children; determine the structure of sensitization to the main allergens of these products using molecular component diagnostics.
Materials and methods. 29 children aged from 3 to 18 years with clinical signs of allergies to fish and seafood were examined, with confirmation of sensitization to them using the ALEX-2 molecular component diagnostic method (Macro Array Diagnostics GmbH, Austria). Levels of specific IgE were determined.
Results. Among those examined, children with food allergies to fish and seafood aged 3-6 years predominated (41.4%). 18 (62.1%) children had a severe allergy history. 19 (65.5%) children had oral allergy syndrome; 18 (62.1%) children had a papular rash with itching. Difficulty breathing was observed in 16 (55.2%) children. About half of the subjects were sensitized to fish allergens, most often to β-parvalbumin. Only 4 (13.8%) children were sensitized to fish enolase and eldolase. Among seafood, sensitization to squid predominated in children - in 18 (62.1%) children, while sensitization to tropomyosin was low - 1 (3.4%) case.
Conclusions. The problem of the appearance of fish and seafood is relevant today, especially among children aged 3-6 years (41.4%). In children with fish allergy, sensitization to β-parvalbumin of different fish species predominated, namely to salmon (51.7%), mackerel (51.7%), herring (48.3%), carp (48.3%), tuna (48.3%), cod (41.4%). As a result of sensitization to seafood, sIGE was more often recorded to extracts of squid (62.1%), oyster (27.6%), lobster (20.7%), mussels (20.7%), clam (17.2%).
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
References
Aibinu IE, Smooker PM, Lopata AL. (2019). Anisakis Nematodes in Fish and Shellfish- from infection to allergies. Int J Parasitol Parasites Wildl. 9: 384-393. Published 2019 Jun 6. https://doi.org/10.1016/j.ijppaw.2019.04.007; PMid:31338296 PMCid:PMC6626974
Ballardini N, Nopp A, Hamsten C et al. (2017). Anaphylactic reactions to novel foods: Case report of a child with severe crocodile meat allergy. Pediatrics. 139(4): e20161404. https://doi.org/10.1542/peds.2016-1404; PMid:28275203
Buyuktiryaki B, Masini M, Mori F, Barni S, Liccioli G, Sarti L et al. (2021). IgE-Mediated Fish Allergy in Children. Medicina. 57(1): 76. https://doi.org/10.3390/medicina57010076; PMid:33477460 PMCid:PMC7830012
Čelakovská J, Bukač J, Vaňková R, Krejsek J, Andrýs C, Krcmova I. (2020). Food allergy to shrimps and fish in patients suffering from atopic dermatitis, the results of ISAC Multiplex examination. Food and Agricultural Immunology. 31; 1: 1061-1078. URL: https://www.tandfonline.com/doi/full/10.1080/09540105.2020.1826911. https://doi.org/10.1080/09540105.2020.1826911
Cermakova E, Lencova S, Mukherjee S, Horka P, Vobruba S, Demnerova K, Zdenkova K. (2023, Jan 3). Identification of Fish Species and Targeted Genetic Modifications Based on DNA Analysis: State of the Art. Foods. 12(1): 228. https://doi.org/10.3390/foods12010228; PMid:36613444 PMCid:PMC9818732
Chokshi NY, Maskatia Z, Miller S et al. (2015). Risk factors in pediatric shrimp allergy. Allergy Asthma Proc. 36(4): 65-71. https://doi.org/10.2500/aap.2015.36.3852; PMid:26108073
Debenedetti ÁL, Madrid E, Trelis M et al. (2019). Prevalence and risk of anisakid larvae in fresh fish frequently consumed in Spain: An overview. Fishes. 4: 1-16. https://doi.org/10.3390/fishes4010013
Dijkema D, Emons JAM, Van de Ven AAJM, Oude Elberink JNG. (2022, Feb). Fish Allergy: Fishing for Novel Diagnostic and Therapeutic Options. Clin Rev Allergy Immunol. 62(1): 64-71. https://doi.org/10.1007/s12016-020-08806-5; PMid:32712803 PMCid:PMC8818006
Elghoudi A, Narchi H. (2022, May 9). Food allergy in children-the current status and the way forward. World J Clin Pediatr. 11(3): 253-269. https://doi.org/10.5409/wjcp.v11.i3.253; PMid:35663006 PMCid:PMC9134150
Faber MA, Pascal M, El Kharbouchi O et al. (2017). Shellfish allergens: tropomyosin and beyond. Allergy. 72: 842. https://doi.org/10.1111/all.13115; PMid:28027402
Feldweg AM. (2017). Food-Dependent, Exercise-Induced Anaphylaxis: Diagnosis and Management in the Outpatient Setting. J Allergy Clin Immunol Pract. 5: 283. https://doi.org/10.1016/j.jaip.2016.11.022; PMid:28283153
Giuffrida MG, Villalta D, Mistrello G, Amato S, Asero R. (2014). Shrimp allergy beyond Tropomyosin in Italy: Clinical relevance of Arginine Kinase, Sarcoplasmic calcium binding protein and Hemocyanin. Eur. Ann. Allergy Clin. Immunol. 46: 172-177.
González-Fernández J, Rivas L, Luque-Ortega JR et al. (2017). Recombinant vs native Anisakis haemoglobin (Ani s 13): Its appraisal as a new gold standard for the diagnosis of allergy. Exp Parasitol. 181: 119-129. https://doi.org/10.1016/j.exppara.2017.08.010; PMid:28818650
Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM et al. (2019). Prevalence and Severity of Food Allergies Among US AdultsPrevalence and Severity of Food Allergies Among US AdultsPrevalence and Severity of Food Allergies Among US Adults. JAMA Network Open. 2(1): e185630-e. https://doi.org/10.1001/jamanetworkopen.2018.5630; PMid:30646188 PMCid:PMC6324316
Hanaoka K, Takahagi S, Ishii K et al. (2020). Type-Ihypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe. Allergol Int. 69(2): 253-260. https://doi.org/10.1016/j.alit.2019.09.007; PMid:31708435
Hoffmann-Sommergruber K, de las Vecillas L, Dramburg S, Hilger C, Santos A. (2022). EAACI Molekular Allergology User's Guide 2.0. URL: https://hub.eaaci.org/resources_documents/molecular-allergology-users-guide-2-0/.
Kalic T, Morel-Codreanu F, Radauer C, Ruethers T, Taki AC, Swoboda I et al. (2019, Feb). Patients Allergic to Fish Tolerate Ray Based on the Low Allergenicity of Its Parvalbumin. J Allergy Clin Immunol Pract. 7(2): 500-508.e11. Epub 2018 Nov 22. https://doi.org/10.1016/j.jaip.2018.11.011; PMid:30471362 PMCid:PMC7060078
Kalic T, Radauer C, Lopata AL, Breiteneder H, Hafner C. (2021). Fish Allergy Around the World-Precise Diagnosis to Facilitate Patient Management. Front Allergy. 2: 732178. Epub 2021 Oct 13. https://doi.org/10.3389/falgy.2021.732178; PMid:35387047 PMCid:PMC8974716
Klueber J, Schrama D, Rodrigues P et al. (2019). Fish allergy management: From component-resolved diagnosis to unmet diagnostic needs. Curr Treat Options Allergy. 6(4): 322-337. https://doi.org/10.1007/s40521-019-00235-w
Kobayashi Y, Kuriyama T, Nakagawara R, Aihara M, Hamada-Sato N. (2016). Allergy to fish collagen: Thermostability of collagen and IgE reactivity of patients' sera with extracts of 11 species of bony and cartilaginous fish. Allergol. Int. 65: 450-458. https://doi.org/10.1016/j.alit.2016.04.012; PMid:27236375
Koeberl M, Clarke D, Lopata AL. (2014). Next generation of food allergen quantification using mass spectrometric systems. J Proteome Res. 13(8): 3499-3509. https://doi.org/10.1021/pr500247r; PMid:24824675
Kuehn A, Codreanu-Morel F, Lehners-Weber C et al. (2016). Crossreactivity to fish and chicken meat - a new clinical syndrome. Allergy. 71(12): 1772-1781. https://doi.org/10.1111/all.12968; PMid:27344988
Linneberg A, Fenger RV, Husemoen LLN, Thuesen BH, Skaaby T, Gonzalez-Quintela A et al. (2013). Association between loss-of-function mutations in the filaggrin gene and self-reported food allergy and alcohol sensitivity. Int. Arch. Allergy Immunol. 161: 234-242. https://doi.org/10.1159/000345949; PMid:23548340
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S et al. (2016). EAACI Molecular Allergology User's Guide. Pediatr. Allergy Immunol. 27: 1-250.
Moonesinghe H, Mackenzie H, Venter C, Kilburn S, Turner P, Weir K et al. (2016). Prevalence of fish and shellfish allergy: a systematic review. Ann Allergy Asthma Immunol. 117: 264-272.e4. https://doi.org/10.1016/j.anai.2016.07.015; PMid:27613460
Moonesinghe H, Patil VK, Dean T, Arshad SH, Glasbey G, Grundy J, Venter C. (2016, Feb). Association between healthy eating in pregnancy and allergic status of the offspring in childhood. Ann Allergy Asthma Immunol. 116(2): Epub 2015 Dec 17. 163-165. https://doi.org/10.1016/j.anai.2015.11.005; PMid:26706295
Muraro A. (2023). IgE-Mediated Shellfish Allergy in Children. Nutrients. 15(12): 2714. https://doi.org/10.3390/nu15122714; PMid:37375617 PMCid:PMC10301456
Nugraha R. Ruethers T, Taki AC, Johnston EB, Karnaneedi S, Kamath SD, Lopata AL. (2022). Recombinant Tropomyosin from the Pacific Oyster (Crassostrea gigas) for Better Diagnosis. Foods. 11: 404. https://doi.org/10.3390/foods11030404; PMid:35159555 PMCid:PMC8834279
Nwaru BI, Hickstein L, Panesar SS, Roberts G, Muraro A, Sheikh A. (2014). The EAACI Food Allergy and Anaphylaxis Guidelines Group. Prevalence of common food allergies in Europe: A systematic review and meta-analysis. Allergy. 69: 992-1007. https://doi.org/10.1111/all.12423; PMid:24816523
Pali-Schöll I, Untersmayr E, Klems M, Jensen-Jarolim E. (2018). The effect of digestion and digestibility on allergenicity of food. Nutrients. 10: 1129. https://doi.org/10.3390/nu10091129; PMid:30134536 PMCid:PMC6164088
Ruethers T, Taki AC, Johnston EB et al. (2018). Seafood allergy: A comprehensive review of fish and shellfish allergens. Mol Immunol. 100: 28-57. https://doi.org/10.1016/j.molimm.2018.04.008; PMid:29858102
Ruethers T, Taki AC, Karnaneedi S et al. (2021). Expanding the allergen repertoire of salmon and catfish. Allergy. 76(5): 1443-1453. https://doi.org/10.1111/all.14574; PMid:32860256
Savage J, Sicherer S, Wood R. (2016). The Natural History of Food Allergy. J Allergy Clin Immunol Pract. 4: 196. https://doi.org/10.1016/j.jaip.2015.11.024; PMid:26968958
Sharp MF, Lopata AL. (2014). Fish allergy: In review. Clin. Rev. Allergy Immunol. 46: 258-271. https://doi.org/10.1007/s12016-013-8363-1; PMid:23440653
Sicherer SH, Sampson HA. (2018). Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 141: 41. https://doi.org/10.1016/j.jaci.2017.11.003; PMid:29157945
Sorensen M, Kuehn A, Mills ENC, Costello CA, Ollert M, Smabrekke L et al. (2017). Cross-reactivity in fish allergy: a double-blind, placebo-controlled food-challenge trial. J Allergy Clin Immunol. 140: 1170-1172. https://doi.org/10.1016/j.jaci.2017.03.043; PMid:28479332
Spolidoro GCI, Amera YT, Ali MM, Nyassi S, Lisik D, Ioannidou A et al. (2023, Feb). Frequency of food allergy in Europe: An updated systematic review and meta‐analysis. Allergy. 78(2): 351-368. Published online 2022 Nov 7. https://doi.org/10.1111/all.15560; PMid:36271775 PMCid:PMC10099188
Stephen JN, Sharp MF, Ruethers T, Taki A, Campbell DE, Lopata AL. (2017). Allergenicity of bony and cartilaginous fish - Molecular and immunological properties. Clin. Exp. Allergy. 47: 300-312. https://doi.org/10.1111/cea.12892; PMid:28117510
Taki AC, Johnston E, Nugraha R, Le TTK, Kalic T, McLean T et al. (2018). Seafood allergy: A comprehensive review of fish and shellfish allergens. Mol. Immunol. 100: 28-57. https://doi.org/10.1016/j.molimm.2018.04.008; PMid:29858102
Tamura M, Matsui K, Kobayashi Y, Ogita C, Tsuboi K, Kusakabe M et al. (2018). A case of eel collagen allergy. Allergol. Int. 67: 138-140. https://doi.org/10.1016/j.alit.2017.04.012; PMid:28583315
Thivalapill N, Andy-Nweye AB, Bilaver LA et al. (2022). Sensitization to house dust mite and cockroach may mediate the racial difference in shellfish allergy. Pediatr Allergy Immunol. 33: e13837. https://doi.org/10.1111/pai.13837; PMid:36003047
Tong WS, Yuen AW, Wai CY, Leung NY, Chu KH, Leung PS. (2018, Oct 8). Diagnosis of fish and shellfish allergies. J Asthma Allergy. 11: 247-260. https://doi.org/10.2147/JAA.S142476; PMid:30323632 PMCid:PMC6181092
Ueno R, Takaoka Y, Shimojo N et al. (2020). A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen. Asia Pac Allergy. 10(4): e35. Published 2020 Oct 5. https://doi.org/10.5415/apallergy.2020.10.e35; PMid:33178560 PMCid:PMC7610083
Viñas M, Pineda F, Izquierdo-Domínguez A et al. (2018). Allergy To Limanda aspera (Yellowfin Sole): Report of a Case of Food Allergy in a Child. J Investig Allergol Clin Immunol. 28: 137. https://doi.org/10.18176/jiaci.0222; PMid:29661744
Wai CYY, Leung NYH, Leung ASY et al. (2022). Comprehending the allergen repertoire of shrimp for precision molecular diagnosis of shrimp allergy. Allergy. 77: 3041. https://doi.org/10.1111/all.15370; PMid:35567339 PMCid:PMC9795902
Wang HT, Warren CM, Gupta RS, Davis CM. (2020). Prevalence and Characteristics of Shellfish Allergy in the Pediatric Population of the United States. Allergy Clin Immunol Pract. 8(4): 1359. Epub 2020 Jan 7. https://doi.org/10.1016/j.jaip.2019.12.027; PMid:31917365 PMCid:PMC7951995
Warren CM, Jiang J, Gupta RS. (2020). Epidemiology and burden of food allergy. Curr. Allergy Asthma Rep. 20: 6. https://doi.org/10.1007/s11882-020-0898-7; PMid:32067114 PMCid:PMC7883751
Xepapadaki P, Christopoulou G, Stavroulakis G et al. (2021). Natural History of IgE-Mediated Fish Allergy in Children. J Allergy Clin Immunol Pract. 9: 3147. https://doi.org/10.1016/j.jaip.2021.04.007; PMid:33866031
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