Diagnosis and treatment of community-acquired pneumonia in preschool children: problems and controversial issues
DOI:
https://doi.org/10.15574/SP.2023.136.98Keywords:
viral pneumonia, bacterial pneumonia, community-acquired pneumonia, diagnosis, childrenAbstract
Community-acquired pneumonia remains one of the most common diseases in preschool children, but despite the intensive study of this pathology, in the practice of a primary care physician, the issue of differential diagnosis and treatment of viral and bacterial pneumonia causes certain problems.
The aim of the study is to determine the problems existing in the practice of a primary care physician regarding the diagnosis and treatment of community-acquired pneumonia in preschool children, to determine ways to solve them, using data from domestic and foreign literature.Modern clinical guidelines for the diagnosis and treatment of community-acquired pneumonia in preschool children at the ambulatory stage were reviewed and analyzed. Med Line, Embase, Web of Science and Scopus databases were analyzed to search for literature sources.Modern epidemiological data on viral and bacterial pneumonia in preschool children are presented. The issue of the role of clinical manifestations and paraclinical research methods in their differential diagnosis is covered. In the context of the problem, an integrated approach to the diagnosis of viral and bacterial pneumonia, which is based on the determination of clinical signs and symptoms, is recommended. Special attention is paid to the issue of the treatment of community-acquired pneumonia in preschool children. A comparative description of the recommendations of national and foreign guidelines and generalized retrospective analyzes regarding the advisability of prescribing and cancelling antibiotics is given. Wider implementation of etiological examination using modern methods is recommended.Conclusions. The final decision regarding the diagnosis of viral or bacterial pneumonia in each specific case should be based on the totality of the anamnesis data, clinical signs and symptoms. The implementation of integrated management of preschool children into the practice of a primary care physician will allow determining the probability of the etiology of pneumonia without auxiliary methods of examination and prescribing empirical therapy during the initial examination.The authors declare no conflict of interest.
References
Bradley JS, Byington CL, Shah SS. (2011). The management of community-asquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases and the Infectious Diseases Society of America. Clin. Infect. Dis. 53(7): 25-76. URL: https://academic.oup.com/cid/article/53/7/e25/424286. https://doi.org/10.1093/cid/cir531; PMid:21880587 PMCid:PMC7107838
CDC. (2020). Pneumococcal Disease. Surveillance and Reporting. URL: https://www.cdc.gov/pneumococcal/surveillance.html.
Dickson RP, Erb-Downward JR, Martinez FJ et al. (2015, Oct 22). The Microbiome and the Respiratory Tract. ARI. 13: 48. https://doi.org/10.1146/annurev-physiol-021115-105238; PMid:26527186 PMCid:PMC4751994
Dudnyk VM, Pasik VLu. (2022). Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers. Modern Pediatrics. Ukraine. 2(122): 32-38. https://doi.org/10.15574/SP.2022.122.32
Evertsena J, Baumgardnera DJ, Regnerya A et al. (2010). Diagnosis and management of pneymonia and bronchitis in outpatient primary care practices. Prim Care Respir J. 19(3): 237-241. https://doi.org/10.4104/pcrj.2010.00024; PMid:20490437 PMCid:PMC3065928
Gadsby NJ, Russell CD, McHudh MP et al. (2016). Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia. Clin Infect Dis. 62(7): 817-823. https://doi.org/10.1093/cid/civ1214; PMid:26747825 PMCid:PMC4787606
Gamache J (ed.), Harrington A, Kamangar N. (2020). Bacterial Pneumonia Workup. URL: https://emedicine.medscape.com/article/300157-workup?form=fpf.
Ginsburg AS, Lenahan JL, Izadnegahdar R et al. (2018). A Systematic Review of Tools to Measuring Respiratory Rate in Order to Identify Childhood Pneumonia. Am J Respir Crit Care Med. 197(9): 1116-1127. https://doi.org/10.1164/rccm.201711-2233CI; PMid:29474107
Harris M, Clark J, Coote N. (2011). British Thoracic Society guideline for the management of community acquired pneumonia in children: update. Thorax. 66; Suppl 2: 1-23. https://doi.org/10.1136/thoraxjnl-2011-200598; PMid:21903691
Jain S, Williams DJ, Arnold SR. (2015). Community acquired pneumonia reguiring hospitalization among U.S. children. N Engl J Med. 372; 9: 835-845. https://dx.doi.org/10/1056/NEJMoa1405870.
Jones BP, Tay ET, Elikashvili I et al. (2016). Feasibility and Safety of Substituting Lung Ultrasonography for Chest Radography When Diagnosing Pneumonia in Children: A Randomized Controlled Trial. Chest. 150: 131-138. https://doi.org/10.1016/j.chest.2016.02.643; PMid:26923626
Kaur K, Mahajan R, Tanwar A. (2013). A novel marker procacitonin mey help stem the antibiotic overuse in emergency setting. Int J Appl Basic Med Res. 3(2): 77-83. https://doi.org/10.4103/2229-516X.117051; PMid:24083140 PMCid:PMC3783672
Kurian J, Kevin TL, Han BK et al. (2009). Comparison of ultrasound and CT in the evaluation of pneumonia complicated by parapneumonic effusion in children. AJR Am J Roentgenol. 193: 1648-1654. https://doi.org/10.2214/AJR.09.2791; PMid:19933660
Le Roux DM, Zar HJ. (2017). Community-acquired pneumonia in children-a changing spectrum of disease. Pediatr Radiol. 47: 1392-1398. https://doi.org/10.1007/s00247-017-3827-8; PMid:29043417 PMCid:PMC5608782
Ministry of Health of Ukraine. (2022). Community-acquired pneumonia in children. Standards of medical care. Order of the Ministry of Health of Ukraine No. 1380, 2.08.2022. URL: https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-02082022--1380-pro-zatverdzhennja-standartiv-medichnoi-dopomogi-pozalikarnjani-pnevmonii-u-ditej.
Mokia-Serbina SA, Litvinova TV, Plokhinov GО. (2016). Community-acquired pneumonia in children: modern approaches to the duration of antibiotic therapy. Child's health. 2 (70): 138-141. ISSN 2224-0551-p ISSN 2307-1168-e URI: http://repo.dma.dp.ua/id/eprint/2124.
MsAllister DA, Health LG. (2019). Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis. Lancet Glob Health. 7(1): e47. https://doi.org/10.1016/S2214-109X(18)30408-X; PMid:30497986
Murdoch DR, O'Brien KL, Driscoll AJ et al. (2012). Laboratory Methods for Determining Pneymonua Etiology in Chldren. Pneumonia Methods Working Group, the PERCH Core Team. Clinical Infectious Diseases. 54; suppl 2: S146-S152. URL: https://academic.oup.com/cid/article/54/suppl2/S146/376724. https://doi.org/10.1093/cid/cir1073; PMid:22403229
Nathan AM, Teh CSJ, Jabar KA, Teoh BT, Tangaperumal A, Westerhout C et al. (2020, Feb 14). Bacterial pneumonia and its associated factors in children from a developing country: A prospective cohort study. PLoS One. 15(2): e0228056. https://doi.org/10.1371/journal.pone.0228056; PMid:32059033 PMCid:PMC7021284
Oliwa JN, Marais BJ. (2017, Mar). Vaccines to prevent pneumonia in children - a developing country perspective. Paediatr Respir Rev. 22: 23-30. Epub 2015 Aug 19. https://doi.org/10.1016/j.prrv.2015.08.004; PMid:26364006 PMCid:PMC6995362
Ortemenka YeP, Andriychuk TR, Solonar YaL et al. (2019). Diagnostic information of clinical markers in the verification of acute infectious-inflammatory processes of the lover respiratory tract in children. Modern pediatrics. Ukraine. 4(100): 18-23. https://doi.org/10.15574/SP.2019.100.18
Pereda MA, Chavez MA, Hooper-Miele CC et al. (2015). Luhg iltrasound for the diagnosis of pneumonia in children: a meta-analysis. Pediatrics. 135: 714-22. https://doi.org/10.1542/peds.2014-2833; PMid:25780071 PMCid:PMC9923609
Pneumonia in children. (2022). Evidence-based clinical guideline. URL: www.dec.gov.
Polepalle T, Moogala S, Boggarapu S et al. (2015). Acute phase proteins and their role in periodontitis: a review. J Clin Diagn Res. 9(11): ZEO1-5. https://doi.org/10.7860/JCDR/2015/15692.6728; PMid:26674303 PMCid:PMC4668538
Popovsky EY, Florin TA, (2021). Community-Acquired Pneumonia in Childhood. Encyclopedia of Respiratory Medicine. 2022: 119-31. Epub 2021 Sep 17. https://doi.org/10.1016/B978-0-08-102723-3.00013-5; PMCid:PMC7458534
Pozalikarniana pnevmonia v ditei vicom 1 misiatsia. (2021). Klinichna nastanova, zasnovana na dokazakh. Modern pediatric. Ukraine. 1(113): 82-111. URL: https://med-expert.com.ua/jurnals/wp-content/uploads/2021/03/13/pdf.
Pritt BS, Aubry MC. (2017). Histopathology of viral infections of the lung. Senin Diagan Pethol. 34(6): 510-517. https://doi.org/10.1053/j.semdp.2017.06.005; PMid:28693907 PMCid:PMC7126518
Ren GL, Wang XF, Xu J, Li J, Meng Q, Xie GQ et al. (2021, Feb 16). Comparison of acute pneumonia caused by SARS-COV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak. Mil Med Res. 8(1): 13. https://doi.org/10.1186/s40779-021-00306-7; PMid:33593415 PMCid:PMC7886299
Schuetz P, Christ-Crain M, Thomann R et al. (2009). Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infection: the ProHOSP randomized controller trial. JAMA. 302(10): 1059-1066. https://doi.org/10.1001/jama.2009.1297; PMid:19738090
Thorburn K, Harigopal S, Reddy V, Taylor N, van Saene HK. (2006, Jul). High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax. 61(7): 611-615. Epub 2006 Mar 14. https://doi.org/10.1136/thx.2005.048397; PMid:16537670 PMCid:PMC2104657
Torres A, Cilloniz C, Niederman MS et al. (2021). Pneumonia. Not Rev Dis Primers. 7(1): 25. https://doi.org/10.1038/s41572-021-00259-0; PMid:33833230
Torres A, Lee N, Cilloniz C et al. (2016). Laboratory diagnosis of pneumonia in the molecular age. European Respiratory Journal. 48: 1764-1778. URL: https://eri.ersjournals.com/content/48/6/1764. https://doi.org/10.1183/13993003.01144-2016; PMid:27811073
Wahl B, O'Brien KL, Greenbaum A et al. (2018). Burden of Streptococcus pneumoniae and Haemophilus influenzae type b diseasein children in the era of conjugate vaccines: global, regional, and national estimates for 2000-15. Lancet Glob Health. 6(7): e744-e757. https://doi.org/10.1016/S2214-109X(18)30247-X; PMid:29903376
Wilmott RW, Bush A, Boat TF, Deterding RR, Ratjen F, Chernick V. (2012). Kendig and Chernik's Disorders of the Respiratory Tract in Children. 8th Edition. Elsevier. URL: https://www.sciencedirect.com/book/9781437719840/kendig-and-chernicks-disorders-of-the-respiratory-tract-in-children.
WHO. (2013). Pocket Book of hospital care for children. Guidelines for the management of common illnesses with limited resources. Second edition. World Health Organization. URL: https://apps.who.int/iris/rest/bitstreams/285978/retrieve.
WHO. (2014). Hospital care for children. Guidelines for the management of common childhood ilinesses. 2nd ed. WHO ERB. URL: https:/www.who.int/maternal-child-adolescen/doc_uments/child.hospital-care/en/.
WHO. (2014). Revised WHO classification and treatment of pneumonia in children at health facilities. Evidence summaries. Geneva: World Health Organization. URL: www.who.int/about/licensing/copyright_form/en/index.html.
World Economic Forum. Global Risks. (2014). Report. URL: https://www.weforum.org/reports/global-risks-2014-report.
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