Magnesium’s role in a healthy person’s body, in the course and rehabilitation after infectious respiratory pathology and COVID-19 (literature information, own data)
DOI:
https://doi.org/10.15574/SP.2023.133.90Keywords:
magnesium, deficiency, asthenic syndrome, rehabilitation, post-COVID-19, correction, childrenAbstract
Magnesium is a macroelement that plays an important role in the regulation of many physiological processes. In the case of insufficient intake of magnesium, which does not meet the needs of the child's body, its deficiency develops. Clinical manifestations of magnesium deficiency are nonspecific and may be similar to symptoms of various diseases, including asthenic syndrome. In turn, asthenic syndrome is common in children who have suffered infectious diseases, COVID-19, influenza, and other acute respiratory infectious pathology. In such children, excessive anxiety, rapid fatigue, sudden mood changes, sleep disorders, and emotional lability can be detected. Given that the leading role in ensuring the proper functioning of most of the body's enzyme systems, tissue respiration, energy exchange, and synthetic processes belongs to magnesium, it is assumed that the development of the described symptoms may be related to its deficiency.
Purpose - to summarize literature data on the role of magnesium in the body of a healthy person, the peculiarities of its metabolism, its importance in the course and rehabilitation after respiratory infectious pathology and COVID-19, signs of deficiency, and methods of its correction; evaluate the results of own research.
Materials and methods. General clinical (analysis of anamnesis data), laboratory (determination of magnesium level in blood serum), statistical, bibliographic, and information-analytic research methods were used. 60 children aged 9 to 18 took part in the study, among them 35 children who had COVID-19 (the first group) and 25 children who did not have COVID-19 (the second group).
Results. It was established that the average value of magnesium level in blood serum in children of the first group was lower than in children of the second group (p=0.005). Individual analysis showed that 31.4% of patients in the first group, who had a term of 4-5 months after COVID-19, noted the presence of post-COVID-19 symptoms, such as excessive fatigue, headache, muscle weakness, impaired sleep, appetite, which coincides with the data of the literature.
Conclusions. The data of our study may indicate the effect of transferred COVID-19 on the level of magnesium in the blood serum, which may be one of the reasons for its deficiency and, accordingly, the development of post-COVID-19 symptoms in children. It is advisable to carry out laboratory determination of the magnesium level in children who had acute respiratory infectious pathology, including COVID-19, to establish the causes of the development of individual symptoms that aggravate the general well-being, prevent the development of magnesium deficiency and find additional ways of rehabilitation after respiratory infectious pathology and COVID-19.
No conflict of interests was declared by the authors.
References
Ahmed F, Mohammed A. (2019). Magnesium: the forgotten electrolyte - a review on hypomagnesemia. Medical Sciences. 7 (4): 56. https://doi.org/10.3390/medsci7040056; PMid:30987399 PMCid:PMC6524065
Barna OM, Kalinichenko MA. (2021). Asthenic syndrome: new challenges - a new approach. Medicine of Ukraine. 4 (250): 25-29. https://doi.org/10.37987/1997-9894.2021.4(250).238120
Bhurat R, Premkumar S, Manokaran RK. (2022). Serum magnesium levels in children with and without migraine: A cross-sectional study. Indian Pediatrics. 59 (8): 623-625. https://doi.org/10.1007/s13312-022-2576-4; PMid:35751375
Caronna E, Pozo‐Rosich P. (2021). Headache during COVID‐19: Lessons for all, implications for the International Classification of Headache Disorders. Headache. 61 (2): 385. https://doi.org/10.1111/head.14059; PMid:33522600 PMCid:PMC8013461
Cleveland Clinic. (2023). Magnesium-Rich Food Information. URL: https://my.clevelandclinic.org/health/articles/15650-magnesium-rich-food.
Di Nicolantonio JJ, O'Keefe JH, Wilson W. (2018). Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open heart. 5 (1): e000668. https://doi.org/10.1136/openhrt-2017-000668; PMid:29387426 PMCid:PMC5786912
Dotan A, David P, Arnheim D, Shoenfeld Y (2022). The autonomic aspects of the post-COVID19 syndrome. Autoimmunity Reviews. 21 (5): 103071. https://doi.org/10.1016/j.autrev.2022.103071; PMid:35182777 PMCid:PMC8848724
Elin RJ. (1987). Assessment of magnesium status. Clin. Chem. 33: 1965-1970. https://doi.org/10.1093/clinchem/33.11.1965; PMid:3315301
Escobedo-Monge MF, Barrado E, Parodi-Román J, Escobedo-Monge MA, Torres-Hinojal MC, Marugán-Miguelsanz JM. (2022). Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases. Nutrients. 14 (14): 2941. https://doi.org/10.3390/nu14142941; PMid:35889897 PMCid:PMC9315923
Glasdam SM, Glasdam S, Peters GH. (2016). The importance of magnesium in the human body: a systematic literature review. Advances in clinical chemistry. 73: 169-193. https://doi.org/10.1016/bs.acc.2015.10.002; PMid:26975973
He FJ, MacGregor GA. (2008). Beneficial effects of potassium on human health. Physiologia plantarum. 133 (4): 725-735. https://doi.org/10.1111/j.1399-3054.2007.01033.x; PMid:18724413
Huang CL, Kuo E. (2007). Mechanism of hypokalemia in magnesium deficiency. Journal of the American Society of Nephrology. 18 (10): 2649-2652. https://doi.org/10.1681/ASN.2007070792; PMid:17804670
Huang YH, Zeng BY, Li DJ, Cheng YS, Chen TY, Liang HY et al. (2019). Significantly lower serum and hair magnesium levels in children with attention deficit hyperactivity disorder than controls: A systematic review and meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 90: 134-141. https://doi.org/10.1016/j.pnpbp.2018.11.012; PMid:30496768
Hyshchak TV, Marushko YuV. (2012). Ctan obminu mahniiu u ditei shkilnoho viku na tli somatychnoi patolohii. Sovremennaia pedyatryia. 8: 30-33.
Jahnen-Dechent W, Ketteler M. (2012). Magnesium basics. Clin. Kidney J. 5: i3-i14. https://doi.org/10.1093/ndtplus/sfr163; PMid:26069819 PMCid:PMC4455825
Kyrytsia N. (2012). Asthenic syndrome in convalescents of infectious mononucleosis Epstein-Barr virus etiology. Ukrainian Scientific Medical Youth Journal. 3 (69): 66-68.
Lopez-Leon S, Wegman-Ostrosky T, del Valle NCA, Perelman C, Sepulveda R, Rebolledo PA et al. (2022). Long COVID in Children and Adolescents: A Systematic Review and Meta-analyses. Sci Rep. 12 (1): 9950. https://doi.org/10.1038/s41598-022-13495-5; PMid:35739136 PMCid:PMC9226045
Marushko YuV, Hyschak TV. (2014). Systemni mekhanizmy adaptatsii. Stres u ditei. Monohrafiia. Kyiv: 138.
Marushko YuV, Hyschak TV. (2016). Obgruntuvannia zastosuvannia preparativ mahniiu v pediatrychnii praktytsi (ohliad literatury). Sovremennaya pedyatriya. 6(78): 27-32. https://doi.org/10.15574/SP.2016.78.27
Marushko YuV, Hyshchak TV, Zlobynets AS. (2012). Zastosuvannia kombinovanoho preparatu mahniiu ta kaliiu u kompleksnii terapii ditei z dyskineziieiu zhovchovyvidnykh shliakhiv ta kardiometabolichnymy porushenniamy. Sovremennaya pedyatriya. 7(47): 1-6.
Marushko YuV, Hyshchak TV. (2012). Vmist mahniiu, kharakterystyka astenichnykh proiaviv ta nichnoho snu v ditei iz riznymy formamy pervynnoi arterialnoi hipertenzii. Zdorove rebenka. 7: 42.
Marushko YuV, Hyshchak TV. (2013). Efektyvnist zastosuvannia Mahne V6 pry astenichnomu syndromi i porushenniakh nichnoho snu u ditei. Sovremennaya pedyatriya. 6 (53): 37-44.
Marushko YuV, Hyshchak TV. (2013). Mahnii ta yoho znachennia dlia dytiachoho orhanizmu. Dytiachyi likar. 1: 9-13.
Marushko YuV, Kostynska NG, Hyshchak TV, Marushko TV. (2022). The biological role of chromium and the impact of changes in its content on the course of obesity and hypertension in children (literature review, own research). Modern Pediatrics. Ukraine. 3 (123): 73-79. https://doi.org/10.15574/SP.2022.123.73
Marushko YuV, Аsonov AO, Hyschak TV. (2019). Rol mahniiu v orhanizmi liudyny ta vplyv zmenshenoho vmistu mahniiu na yakist zhyttia ditei iz hastroezofahealnoiu refliuksnoiu khvoroboiu. Sovremennaya pedyatriya. 1 (97): 124-130. https://doi.org/10.15574/SP.2019.97.124
Marushko YuV. (2016). Rol ta mistse defitsytu mahniiu v rozvytku vehetosudynnoi dysfunktsii u ditei. Zdorove rebenka. 4: 43-48.
Meyers LD, Suitor CW. (Eds.). (2007). Dietary reference intakes research synthesis: workshop summary. National Academies Press.
Nieder R, Benbi DK, Reichl FX. (2018). Microelements and their role in human health. In Soil Components and Human Health. Springer, Dordrecht: 317-374. https://doi.org/10.1007/978-94-024-1222-2_7
Ohyama T. (2019). New aspects of magnesium function: a key regulator in nucleosome self-assembly, chromatin folding and phase separation. International journal of molecular sciences. 20 (17): 4232. https://doi.org/10.3390/ijms20174232; PMid:31470631 PMCid:PMC6747271
Ozmen H, Akarsu S, Polat F, Cukurovali A. (2013). The levels of calcium and magnesium, and of selected trace elements, in whole blood and scalp hair of children with growth retardation. Iranian Journal of Pediatrics. 23 (2): 125.
Pickering RT, Bradlee ML, Singer MR, Moore LL. (2021). Higher intakes of potassium and magnesium, but not lower sodium, reduce cardiovascular risk in the Framingham Offspring Study. Nutrients. 13 (1): 269. https://doi.org/10.3390/nu13010269; PMid:33477824 PMCid:PMC7832857
Reddy P, Edwards LR. (2019). Magnesium supplementation in vitamin D deficiency. American journal of therapeutics. 26 (1): e124-e132. https://doi.org/10.1097/MJT.0000000000000538; PMid:28471760
Ross CA, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. (2014). Modern Nutrition in Health and Disease. 11th ed. Lippincott Williams & Wilkins: Baltimore, MD, USA: 159-175.
Seluk ММ, Kosachok ММ, Lоvkin ІМ, Seluk ОV, Yavorska ІS, Pylypenko МА. (2022). The use of a complex based on magnesium and potassium (Panzikor) on the course of arterial hypertension of I-II stage 1-2 degree with hypokalemia. Modern Pediatrics. Ukraine. 7 (127): 134-139. https://doi.org/10.15574/SP.2022.127.134
Song J, She J, Chen D, Pan F. (2020). Latest research advances on magnesium and magnesium alloys worldwide. Journal of Magnesium and Alloys. 8 (1): 1-41. https://doi.org/10.1016/j.jma.2020.02.003
Suslyk HI, Lishchuk OZ. (2016). Stan makro- ta mikroelementnoho zabezpechennia u khvorykh na tsukrovyi diabet 2 typu z ozhyrinniam. Zdobutky klinichnoi i eksperymentalnoi medytsyny. (2): 140-140.
Tang CF, Ding H, Jiao RQ, Wu XX, Kong LD. (2020). Possibility of magnesium supplementation for supportive treatment in patients with COVID-19. European Journal of Pharmacology. 886: 173546. https://doi.org/10.1016/j.ejphar.2020.173546; PMid:32931782 PMCid:PMC7486870
Vysochyna IL, Kramarchuk VV, Yashkina TO. (2021). Postvirusnyi astenichnyi syndrom u ditei: chy potribna dopomoha? Zdorov'e Rebenka. 16 (6): 425-434. https://doi.org/10.22141/2224-0551.16.6.2021.241720
Weaver CM. (2013). Potassium and health. Advances in Nutrition. 4 (3): 368S-377S. https://doi.org/10.3945/an.112.003533; PMid:23674806 PMCid:PMC3650509
World Health Organization. (2012). Guideline: potassium intake for adults and children. World Health Organization.
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