Juvenile systemic sclerosis in children (clinical case)
DOI:
https://doi.org/10.15574/SP.2022.125.128Keywords:
child, immunological markers, intima-media complex, capillaroscopy, treatmentAbstract
The up-to-date data on origin, diagnostic approach and treatment of juvenile systemic scleroderma in the child with the disease onset at early age are presented in the article. The diagnostic value of anamnesis and clinical data, laboratory and instrumental methods of investigation, in particular, identification of juvenile systemic scleroderma immunological markers, ultrasound Doppler scan of vessels as well as capillaroscopy of the nail bed are covered.The main data of instrumental examinations for the diagnosis were pulmonary fibrosis, decreased cardiac ejection fraction of left ventricles, large-focal cardiosclerosis, thickening of the intima-media complex, signs of peripheral vascular Raynaud's phenomenon. The diagnostic laboratory markers are increased titers of antibodies to native and denatured DNA, antibodies to nucleosomes, antibodies to Scl-70, circulating immune complexes and CRP. The treatment regimen should be developed individually and be aimed at deceleration of the progression of the autoimmune process.The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.No conflict of interests was declared by the authors.
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