The significance of Staphylococcus aureus skin colonization and the yeast Malassezia in children for the development of atopic dermatitis
DOI:
https://doi.org/10.15574/SP.2022.122.39Keywords:
Staphylococcus aureus, Malassezia, atopic dermatitis, childrenAbstract
Patients with atopic dermatitis have a disrupted epidermal barrier, which is one of the prerequisites for the colonization of bacteria and fungi on the affected skin.
Purpose - to investigate the presence of Staphylococcus aureus and Malassezia species skin colonization in patients with atopic dermatitis.
Materials and methods. Skin swabs were taken in 83 patients with atopic dermatitis and 70 healthy children to determine Staphylococcus aureus skin colonization. The level of Malassezia colonization in the samples was determined by polymerase chain reaction.
Results. The affected skin in patients with atopic dermatitis was significantly more often colonized with Staphylococcus aureus than in healthy children (OR=3.974 (1.861-8.486)). SCORAD was significantly higher in Staphylococcus aureus carriers (p<0.05). In the subgroup of Staphylococcus aureus carriers, children were older and the duration of disease was longer (p<0.05). Malassezia restricta and Malassezia globosa were found in 11 patients with atopic dermatitis and 10 healthy children. The prevalence of Malassezia by species depended on sex and the presence of atopic dermatitis.
Conclusions. Staphylococcus aureus skin colonization is significantly more prevalent in children with atopic dermatitis than in healthy people. Malassezia species are common on the skin of both patients with atopic dermatitis and healthy people, but the ratio of species may vary depending on the presence of disease.
The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the author.
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