Cetirizine is an effective and safe antihistamine (literature review, results of clinical researches)
DOI:
https://doi.org/10.15574/SP.2021.120.55Keywords:
Cetirizine, antihistamines, allergy, H1-receptors, allergic rhinitis, urticariaAbstract
The annual increase in the number of allergic diseases among children and adults determines the search for safe and effective medicine for the treatment of allergies. Today, cetirizine is one of the most well$known antihistamines, which is the «gold standard» in the symptomatic treatment of allergies. It quickly relieves allergy symptoms by entering into a competitive blockade with histamine in 20 minutes after ingestion due to high selectivity for H1$receptors. The most effective is the use of this medicine in allergic manifestations such as sneezing, rhinorrhea, tearing, skin rash. One of the main advantages of cetirizine is high safety, which allows the use it in pediatric practice from 6 months age, and numerous studies confirm this.
No conflict of interest was declared by the authors.
References
AAAAI. (2020, Sep 28). Increasing rates of allergies and asthma. American Academy of Allergy ASthma and Immunology. URL: https://www.aaaai.org/conditions-and-treatments/library/allergy-library/prevalence-of-allergies-and-asthma.
Allegra L, Paupe J, Wieseman HG, Baelde Y. (1993). Cetirizine for seasonal allergic rhinitis in children aged 2-6 years. A double-blind comparison with placebo. Pediatr Allergy Immunol. 4 (3): 157-161. https://doi.org/10.1111/j.1399-3038.1993.tb00085.x; PMid:8220804
Canonica GW, Blaiss M. (2011). Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: a review of the evidence. World Allergy Organ J. 4 (2): 47-53. https://doi.org/10.1097/WOX.0b013e3182093e19; PMid:23268457 PMCid:PMC3500039
Ciprandi G, Passalacqua G, Mincarini M, Ricca V, Canonica GW. (1997). Continuous Versus On Demand Treatment with Cetirizine for Allergic Rhinitis, Annals of Allergy, Asthma & Immunology. 79 (6): 507-511. ISSN 1081-1206. https://doi.org/10.1016/S1081-1206(10)63057-8
Ciprandi G, Tosca MA, Milanese M et al. (2004). Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. Eur Ann Allergy Clin Immunol. 37: 237-240.
EAACI. (2016, Aug). Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 11-15 June 2016. Vienna, Austria. Allergy. 71 (102): 3-633. https://doi.org/10.1111/all.12970; PMid:27542009
FDA. (2021). Drugs. Food and Drug Administration. The Center for Drug Evaluation and Research (CDER). URL: https://www.fda.gov/drugs.
Kondyurina EG, Elkina TN, Gribanova OA. (2013). Tsetirizin v praktike pediatra. Originalnaya statya opublikovana na sayte RMZh. Russkiy meditsinskiy zhurnal. URL: https://www.rmj.ru/articles/pediatriya/Cetiri zin_v_praktike_pediatra/#ixzz7EFRPDoxG.
Lee CF, Sun HL, Lu KH, Ku MS, Lue KH. (2009). The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. Pediatr Allergy Immunol. 20 (5): 493-499. https://doi.org/10.1111/j.1399-3038.2008.00816.x; PMid:19175892
Masi M, Candiani R, van de Venne H. (1993). A placebo-controlled trial of cetirizine in seasonal allergic rhino-conjunctivitis in children aged 6 to 12 years. Pediatr Allergy Immunol. 4 (4): 47-52. https://doi.org/10.1111/j.1399-3038.1993.tb00339.x; PMid:8353660
Naqvi A, Gerriets V. (2021). Cetirizine. StatPearls. Treasure Island (FL): StatPearls Publishing. URL: https://www.ncbi.nlm.nih.gov/books/NBK549776/.
Nayak AS, Berger WE, LaForce CF, Urdaneta ER, Patel MK, Franklin KB, Wu MM. (2017). Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc. 38 (3): 222-230. https://doi.org/10.2500/aap.2017.38.4050; PMid:28441993
NHS. (2020). Guidelines for the treatment of Chronic Spontaneous Urticaria in adult patients. North Central London Joint Formulary Committee: 14.
Nwaru BI, Hickstein L, Panesar SS, Roberts G, Muraro A, Sheikh A. (2014, Aug). EAACI Food Allergy and Anaphylaxis Guidelines Group. Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy. 69 (8): 992-1007. Epub 2014 May 10. https://doi.org/10.1111/all.12423; PMid:24816523
Ostrom NK. (2014, May-Jun). The history and progression of treatments for allergic rhinitis. Allergy Asthma Proc. 35 (1): 3-10. https://doi.org/10.2500/aap.2014.35.3758; PMid:25582156
Pawankar R. (2014). Allergic diseases and asthma: a global public health concern and a call to action. World Allergy Organ J. 7: 1-3. https://doi.org/10.1186/1939-4551-7-12; PMid:24940476 PMCid:PMC4045871
Pearlman DS, Lumry WR, Winder JA, Noonan MJ. (1997). Once-daily cetirizine effective in the treatment of seasonal allergic rhinitis in children aged 6 to 11 years: a randomized, double-blind, placebo-controlled study. Clin Pediatr. 36 (4): 209-215. https://doi.org/10.1177/000992289703600405; PMid:9114992
Pillai S, Abbas AK, Wilson A. (2011). Cellular and Molecular Immunology: with STUDENT CONSULT. Philadelphia: Saunders. ISBN 978-1-4377-1528-6.
Piovani D, Clavenna A, Bonati M, PeFAB group. (2014). Review of Italian primary care paediatricians identifies 38 commonly prescribed drugs for children. Acta Paediatr. 103 (12): e532-537. Epub 2014 Oct 2. https://doi.org/10.1111/apa.12783; PMid:25164591
Portnoy JM, Dinakar C. (2004, Jan). Review of cetirizine hydrochloride for the treatment of allergic disorders. Expert Opin Pharmacother. 5 (1): 125-135. https://doi.org/10.1517/14656566.5.1.125; PMid:14680442
Rossi S. (2012). Australian Medicines Handbook 2012. Adelaide: Australian Medicines Handbook. ISBN 978-0-9805790-6-2.
Sanchez-Borges M, Ansotegui IJ. (2019, Aug). Second generation antihistamines: an update. Curr Opin Allergy Clin Immunol. 19 (4): 358-364. https://doi.org/10.1097/ACI.0000000000000556; PMid:31169593
Simons FE. (2001). Prevention of acute urticaria in young children with atopic dermatitis. J Allergy Clin Immunol. 107 (4): 703-706. https://doi.org/10.1067/mai.2001.113866; PMid:11295661
Spiller HA, Villalobos D, Benson BE, Krenzelok EP, Anderson AD. (2002). Retrospective evaluation of cetirizine (zyrtec) ingestion. J Toxicol Clin Toxicol. 40 (4): 525-526.
Tereschenko E. (2015). Tsetirizin v lechenii allergicheskogo rinita: voprosyi i otvetyi. Pulmonolohiia. Na zamitku alerholohu. Zdorovia Ukrainy. URL: https://health-ua.com/wp-content/uploads/2015/12/35Stranitsyi-iz-OptimZU_pulmo-3_2015_for_site.pdf.
Thomsen SF. (2015). Epidemiology and natural history of atopic diseases. Eur Clin Respir J: 2. https://doi.org/10.3402/ecrj.v2.24642; PMid:26557262 PMCid:PMC4629767
van den Elzen MT, van Os-Medendorp H, van den Brink I et al. (2017). Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria. Clin Transl Allergy. 7: 4. Published 2017 Feb 14. https://doi.org/10.1186/s13601-017-0141-3; PMid:28289538 PMCid:PMC5309999
Warner JO, ETAC Study Group. (2001). Early Treatment of the Atopic Child. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up. J Allergy Clin Immunol. 108 (6): 929-937. https://doi.org/10.1067/mai.2001.120015; PMid:11742270
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