Influence of vitamin D provision on the course of acute respiratory infections in children

Authors

DOI:

https://doi.org/10.15574/SP.2021.119.73

Keywords:

vitamin D, children, deficiency, respiratory diseases, prevention

Abstract

The review article provides data from modern studies confirming the multifaceted effect of vitamin D in the human body. Vitamin D3 receptors (VDRs) have been shown to be present in most organs and tissues of the body. This confirms the importance of vitamin D not only in the formation of the skeletal system, but also in many of its extraosseous effects. Calcitriol affects the modulation of cell growth, neuromuscular conduction, inflammation processes, and is also an important stimulator of innate immunity due to the synthesis of antimicrobial peptides that provide protection against bacteria and viruses. In recent years, the relationship between the concentration of vitamin D in the blood and the incidence of respiratory infections in children has been actively studied. Many studies have shown that low vitamin D status is characteristic of most children with respiratory infections, and an adequate level of 25(OH)D in serum has a positive effect on the frequency of these infections and the severity of their course. Most authors demonstrate the benefits of vitamin D supplementation in the prevention of respiratory diseases in children, but there is no consensus regarding the frequency and dosage of vitamin D.

The authors declare that they have no conflicts of interest.

References

Aglipay M, Birken CS, Parkin PC et al. (2017). Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children. JAMA. 318: 245. https://doi.org/10.1001/jama.2017.8708; PMid:28719693 PMCid:PMC5817430

Ali N. (2020). Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 13 (10): 1373-1380. https://doi.org/10.1016/j.jiph.2020.06.021; PMid:32605780 PMCid:PMC7305922

Alipio M. (2020). Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19). SSRN 3571484. https://doi.org/10.2139/ssrn.3571484

Antypkin YH, Kvashnina LV, Omelchenko LI. (2017). Obgruntuvannia doz vitaminu D3 dlia profilaktyky D-vitaminnoi nedostatnosti ta vitamin D-defitsytnykh staniv u zdorovykh ditei riznoho viku. Informatsiinyi lyst. Kyiv: 63.

Asghari A, Bagheri Z, Jalessi M, Salem MM, Amini E, GhalehBaghi S, Bakhti S. (2017). Vitamin D Levels in Children with Adenotonsillar Hypertrophy and Otitis Media with Effusion. Iran J Otorhinolaryngol. 29 (90): 29-33.

Bikle D, Christakos S. (2020). New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 16 (4): 234-252. https://doi.org/10.1038/s41574-019-0312-5; PMid:32029884

Buonsenso DE, Masiello RC, Valentini P. (2017). Vitamin D and Tuberculosis in Children: A Review Vitamin D and Tuberculosis. J Vaccines Immunol: 108. https://doi.org/10.29011/2575-789X.000108

Caprio M, Infante M, Calanchini M, Mammi C, Fabbri A. (2017). Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. Eat Weight Disord. 22 (1): 27-41. https://doi.org/10.1007/s40519-016-0312-6; PMid:27553017

Cariolou M, Cupp MA, Evangelou E, Tzoulaki I, Berlanga-Taylor AJ. (2019). Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: A systematic review and meta-analysis. BMJ Open. 22; 9 (5): e027666. https://doi.org/10.1136/bmjopen-2018-027666; PMid:31122993 PMCid:PMC6538078

Cayir A, Turan MI, Ozkan O, Cayir Y. (2014). Vitamin D levels in children diagnosed with acute otitis media. J Pak Med Assoc. 64 (11): 1274-1277.

Chowdhury R, Taneja S, Bhandari N, Sinha B, Upadhyay RP, Bhan MK, Strand TA. (2017). Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis. PLoS One. 12 (3): e0170509. https://doi.org/10.1371/journal.pone.0170509; PMid:28273084 PMCid:PMC5342185

Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. (2016). Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. PhysiolRev. 96 (1): 365-408. https://doi.org/10.1152/physrev.00014.2015; PMid:26681795 PMCid:PMC4839493

Collak A, Bozaykut A, Demirel B, Sezer RG, Seren LP, Dogru M. (2014). Serum vitamin D levels in children with recurrent tonsillopharyngitis. North Clin Istanb. 1 (1): 13-18. https://doi.org/10.14744/nci.2014.76486; PMid:28058296 PMCid:PMC5175018

Dankers W, Colin EM, van Hamburg JP, Lubberts E. (2017). Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential. Front Immunol. 7: 697. https://doi.org/10.3389/fimmu.2016.00697; PMid:28163705 PMCid:PMC5247472

Demer LL, Hsu JJ, Tintut Y. (2018). Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. Circ Res. 122 (11): 1576-1585. https://doi.org/10.1161/CIRCRESAHA.118.311585; PMid:29798901 PMCid:PMC6122607

Eroglu C, Demir F, Erge D, Uysal P, Kirdar S, Yilmaz M et al. (2019). The relation between serum vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing. Allergol Immunopathol. 47: 591-597. https://doi.org/10.1016/j.aller.2019.05.002; PMid:31477398 PMCid:PMC7130971

Glicio EJ. (2020). Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report. Rochester, NY: Social Science Research Network. URL: https://papers.ssrn.com/abstract=3593258.

Golan-Tripto I, Loewenthal N, Tal A, Dizitzer Y, Baumfeld Y, Goldbart A. (2021). Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study. BMC Pediatr. 21 (1): 211. https://doi.org/10.1186/s12887-021-02666-4; PMid:33931018 PMCid:PMC8085105

Gou X, Pan L, Tang F, Gao H, Xiao D. (2018). The association between vitamin D status and tuberculosis in children: A meta-analysis. Medicine (Baltimore). 97 (35): e12179. https://doi.org/10.1097/MD.0000000000012179; PMid:30170465 PMCid:PMC6392646

Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. (2020, Apr 2). Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 12 (4): 988. https://doi.org/10.3390/nu12040988; PMid:32252338 PMCid:PMC7231123

Haugen J, Basnet S, Hardang IM, Sharma A, Mathisen M, Shrestha P et al. (2017). Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia. Pediatr Res. 82 (6): 986-993. https://doi.org/10.1038/pr.2017.71; PMid:28678771

Holick MF. (2007). Vitamin D deficiency. N Engl J Med. 357: 266-281. https://doi.org/10.1056/NEJMra070553; PMid:17634462

Holick MF. (2017). The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 18: 153-165. https://doi.org/10.1007/s11154-017-9424-1; PMid:28516265

Hollams EM, Teo SM, Kusel M, Holt BJ, Holt KE, Inouye M, De Klerk NH, Zhang G, Sly PD, Hart PH, Holt PG. (2017). Vitamin D over the first decade and susceptibility to childhood allergy and asthma. J Allergy Clin Immunol. 139 (2): 472-481. https://doi.org/10.1016/j.jaci.2016.07.032; PMid:27726947

Hurwitz JL, Jones BG, Penkert RR, Gansebom S, Sun Y, Tang L et al. (2017). Low Retinol Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection. J Pediatr. 187: 323-327. https://doi.org/10.1016/j.jpeds.2017.04.061; PMid:28578159 PMCid:PMC5588918

Inamo Y, Hasegawa M, Saito K, Hayashi R, Ishikawa T, Yoshino Y et al. (2011). Serum vitamin D concentrations and associated severity of acute lower respiratory tract infections in Japanese hospitalized children. Pediatr Int. 53 (2): 199-201. https://doi.org/10.1111/j.1442-200X.2010.03224.x; PMid:21648117

Jadhav S, Khanwelkar C, Jadhav A, Seshla S. (2021). Vitamin D supplementation in the prevention of recurrent acute respiratory tract infections in children aged <5 years. J Med Sci. 41: 129-133. https://doi.org/10.4103/jmedsci.jmedsci_101_20

Jat KR. (2017). Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies. Trop Doct. 47 (1): 77-84. https://doi.org/10.1177/0049475516644141; PMid:27178217

Jolliffe DA, Camargo CA Jr, Sluyter JD, Aglipay M et al. (2020). Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials. medRxiv. https://doi.org/10.1101/2020.07.14.20152728

Jolliffe DA, Griffiths CJ, Martineau AR. (2013). Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. J Steroid Biochem Mol Biol. 136: 321-329. https://doi.org/10.1016/j.jsbmb.2012.11.017; PMid:23220552

Kvashnina LV, Majdan IS. (2020). Vpliv vitaminu D na stan imunnoyi sistemi v period pandemiyi COVID 19 (novitni dani). Klinichna imunologiya. Alergologiya. Infektologiya. 7 (128): 22-30.

Lau FH, Torabi MR, Saeg F, Hoffman R, Cirillo JD, Greiffenstein P. (2020). Vitamin D insufficiency is prevalent in severe COVID-19. medRxiv. https://doi.org/10.1101/2020.04.24.20075838

Mandal A, Sahi PK. (2017). Serum Vitamin D Levels in Children with Recurrent Respiratory Infections and Chronic Cough: Correspondence. Indian J Pediatr. 84 (2): 172-173. https://doi.org/10.1007/s12098-016-2224-x; PMid:27641972

Marik PE, Kory P, Varon J. (2020). Does vitamin D status impact mortality fromSARS-CoV-2 infection? Med Drug Discov: 100041. https://doi.org/10.1016/j.medidd.2020.100041; PMid:32352080 PMCid:PMC7189189

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P et al. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 356: i6583. https://doi.org/10.1136/bmj.i6583; PMid:28202713 PMCid:PMC5310969

Marushko YuV, Hyshchak TV. (2021). Prevention of vitamin D deficiency in children. The state of the problem in the world and in Ukraine. Modern Pediatrics. Ukraine. 4 (116): 36-45. https://doi.org/10.15574/SP.2021.116.36

McArdle AJ et al. (2020). Vitamin D deficiency is associated with tuberculosis disease in British children. Int J Tuberc Lung Dis. 24: 782-788. https://doi.org/10.5588/ijtld.19.0626; PMid:32912382

McNally JD, Leis K, Matheson LA, Karuananyake C, Sankaran K, Rosenberg AM. (2009). Vitamin D deficiency in young children with severe acute lower respiratory infection. Pediatr Pulmonol. 44 (10): 981-988. https://doi.org/10.1002/ppul.21089; PMid:19746437

McNally JD, Nama N, O'Hearn K, Sampson M, Amrein K, Iliriani K et al. (2017). Vitamin D deficiency in critically ill children: a systematic review and meta-analysis. Crit Care. 23; 21 (1): 287. https://doi.org/10.1186/s13054-017-1875-y; PMid:29169388 PMCid:PMC5701429

NICE. (2021). National policy and strategy for preventing National policy and strategy for preventing vitamin D deficiency. URL: https://pathways.nice.org.uk/pathways/vitamin-d-supplement-use-in-specific-population-groups/national-policy-and-strategy-for-preventing-vitamin-d-deficiency.

Oktaria V, Danchin M, Triasih R, Soenarto Y, Bines JE, Ponsonby AL et al. (2021). The incidence of acute respiratory infection in Indonesian infants and association with vitamin D deficiency. PLoS One. 16 (3): e0248722. https://doi.org/10.1371/journal.pone.0248722; PMid:33755666 PMCid:PMC7987198

Pereira M, Dantas Damascena A, Galvao Azevedo LM, de Almeida Oliveira T, da Mota Santana J. (2020). Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Crit Rev Food Sci Nutr. 4: 1-9. https://doi.org/10.1080/10408398.2020.1841090

Pham H, Rahman A, Majidi A, Waterhouse M, Neale RE. (2019). Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 16 (17): 3020. Published 2019 Aug 21. https://doi.org/10.3390/ijerph16173020; PMid:31438516 PMCid:PMC6747229

Ponnarmeni S, Kumar Angurana S, Singhi S, Bansal A, Dayal D, Kaur R, Patial A, Verma Attri S. (2016). Vitamin D deficiency in critically ill children with sepsis. Paediatr Int Child Health. 36 (1): 15-21. https://doi.org/10.1179/2046905515Y.0000000042; PMid:26120004

Povoroznyuk VV, Balacka NI. (2013). Deficit vitaminu D u naselennya Ukrayini ta chinniki riziku jogo rozvitku. Reprodukt endokrinol. 5 (13): 7-13.

Rhodes JM, Subramanian S, Laird E, Griffin G, Kenny RA. (2021). Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis. J Intern Med. 289 (1): 97-115. https://doi.org/10.1111/joim.13149; PMid:32613681 PMCid:PMC7361294

Sengupta T, Majumder R, Majumder S. (2021). Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives. Mol Cell Biochem. 476 (6): 2421-2427. https://doi.org/10.1007/s11010-021-04093-6; PMid:33604809 PMCid:PMC7891480

Shin YH, Yu J, Kim KW, Ahn K, Hong SA. (2013). Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA). Korean J Pediatr. 56 (10): 439-445. https://doi.org/10.3345/kjp.2013.56.10.439; PMid:24244212 PMCid:PMC3827492

Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB. (2016). The vitamin D receptor regulates tissue resident macrophage response to injury. Endocrinology. 157: 4066-4075. https://doi.org/10.1210/en.2016-1474; PMid:27526034 PMCid:PMC5045513

Taylor SN. (2020). Vitamin D in Toddlers, Preschool Children, and Adolescents. AnnNutrMetab. 76 (2): 30-40. https://doi.org/10.1159/000505635; PMid:33232959

Vertegel AA, Ovcharenko LS. (2014). The vitamin D sufficiency in children with recurrent bronchitis. GeorgianMedNews. 231: 55-59.

Vo P, Koppel C, Espinola JA, Mansbach JM, Celed?n JC, Hasegawa K, Bair-Merritt M, Camargo CA Jr. (2018). Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity. J Pediatr. 203: 416-422.e1. https://doi.org/10.1016/j.jpeds.2018.07.097; PMid:30243543

Wang JW, Hogan PG, Hunstad DA, Fritz SA. (2015). Vitamin D sufficiency and Staphylococcus aureus infection in children. Pediatr Infect Dis J. 34 (5): 544-545. https://doi.org/10.1097/INF.0000000000000667; PMid:25860535 PMCid:PMC4400212

Yakoob MY, Salam RA, Khan FR, Bhutta ZA. (2016). Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 11 (11): CD008824. https://doi.org/10.1002/14651858.CD008824.pub2; PMid:27826955 PMCid:PMC5450876

Zhang QY, Yan ZB, Meng YM et al. (2021). Antimicrobial peptides: mechanism of action, activity and clinical potential. Military Med Res. 8: 48. https://doi.org/10.1186/s40779-021-00343-2; PMid:34496967 PMCid:PMC8425997

Published

2021-11-29

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Section

Practical doctor school