State of iodine supply of children with chronic somatic diseases




iodine deficiency, school-age children, the level of iodine excretion


One of the most common conditions resulting from micronutrient deficiency is iodine deficiency.

Purpose — to evaluate the current state of iodine supply in schoolchildren living in the North-Eastern region of Ukraine, including children with digestive diseases and inflammatory joint diseases.

Materials and methods. Target group: 86 people (11.8±2.71 years), which included patients with digestive diseases (DD) (26.7%) and juvenile idiopathic arthritis (JIA) (60.5%). Methods: dietary iodine intake evaluation by urinary iodine concentration (Sandell–Kolthoff reaction), followed by calculation of the median.

Results. Median urinary iodine excretion was at the lower normal range and amounted to 104.98 μg/l [QR: 59.8; 180.1] in the examined children. Only 51.2% of children had adequate iodine provision; mild iodine deficiency (ID) was diagnosed in 29.1% (Ме=81,91μg/l [QR: 64.26; 90.58]); moderate — 17.4% (Ме=36,19 μg/l [QR: 33.54; 42.24]); severe — in 2.3% of the surveyed (Ме 14,02 μg/l [QR: 12.34; 15.70]). The median urinary iodine excretion in children with somatic diseases was significantly lower than in children of the control group and amounted to 97.26 μg/l [QR 53.7; 148.3] versus 183.71 μg/l [QR 104.4; 287.4], (p=0.003).

Conclusions. School-age children have a high incidence of iodine deficiency (51.2%). Often encountered in childhood diseases (DD and JIA) are accompanied by insufficiency of iodine supply.

The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies.

No conflict of interest was declared by the author.


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