Practical aspects of Lyme disease in children

Authors

  • N.V. Banadyha I. Horbachevsky Ternopil State Medical University of the Ministry of Health of Ukraine, Ukraine
  • I.O. Rogalskyy I. Horbachevsky Ternopil State Medical University of the Ministry of Health of Ukraine, Ukraine

Keywords:

Lyme disease, children, diagnosis, treatment, prevention

Abstract

Lyme disease is especially important in the spring–autumn period, despite the fact that its clinical manifestations may be throughout the year. Awareness of general practitioners with this problem is insufficient, it requires additional knowledge about diagnosis and treatment. In pediatric practice, the fact of a child being bitten by an Ixodes mite that carries the causative agent of Lyme borreliosis, in addition to babesiosis, anaplasmosis, often goes unnoticed. Therefore, parents seek medical help only when various problems arise, often the thought of Lyme disease does not even arise. Lyme disease has a wide polymorphism of clinical symptoms, is characterized by multisystem lesions, cyclical course — all this complicates the diagnostic search. The difficulty also lies in the fact that there are no domestic clinical recommendations. This publication presents approaches to the diagnosis, treatment, prevention of Lyme disease based on the experience of experts from different countries. Modern approaches to two-stage laboratory diagnostics, tactics of patient management from the moment of bite, treatment at different stages of Lyme borreliosis are analyzed. Attention is paid to the need for epidemiological research in Ukraine and the beginning of educational programs to prevent the disease. The differentiated approach to the treatment of Lyme disease in children due to age aspects, concomitant pathology, safety of long_term antibacterial therapy should be studied more.

References

Banadyha NV. (2019). Lyme Disease in Children: Current State of the Problem. Pediatrics Eastern Europe. 7(2): 374–384.

Banadyha N, Rogalskyy I, Komorovsky R. (2019). A Case of Diagnosis of Lyme Disease in the Absence of a Tick Bite. Pediatrics and Neonatology.60(6): 693-694. https://doi.org/10.1016/j.pedneo.2019.06.001; PMid:31248824

Bransfield RC, Aidlen DM, Cook MJ, Javia S. (2020). A Clinical Diagnostic System for Late-Stage Neuropsychiatric Lyme Borreliosis Based upon an Analysis of 100 Patients. Healthcare. 8: 13. https://doi.org/10.3390/healthcare8010013; PMid:31935905 PMCid:PMC7151210

Cameron DJ, Johnson LB, Maloney EL. (2014). Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease. https://www.ilads.org/patient-care/ilads-treatment-guidelines/. https://doi.org/10.1586/14787210.2014.940900; PMid:25077519 PMCid:PMC4196523

Horowitz RI, Lacout A, Marcy PY, Perronne C. (2017). To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis. Clin Microbiol Infect. 24(2): 210. https://doi.org/10.1016/j.cmi.2017.09.015; PMid:29030171

Kimberlin DW, Brady MT, Jackson MA. (2018). American Academy of Pediatrics. Lyme disease. Red Book: report of the Committee of Infections Diseases: American Academy of Pediatrics. 515–523. https://redbook.solutions.aap.org/chapter.aspx?sectionid=189640125&bookid=2205.

Maloney EL. (2020). Applying Basic Concepts in Laboratory Testing to Serologic Testing for Lyme Disease. https://lymediseaseassociation.org/about-lyme/lyme-tbd-testing/current-lyme-disease-testing-by-elizabeth-maloney-md/.

National Institute for Health and Care Excellence (UK). (2018). NICE guideline 95: Lyme disease. https://www.nice.org.uk/guidance/ng95.

Scott JD, Clark KL,Anderson JF, Foley JE, Young MR, Durden LA. (2017). Lyme Disease Bacterium, Borrelia burgdorferi Sensu Lato, Detected in Multiple Tick Species at Kenora, Ontario, Canada. Journal of Bacteriology and Parasitology. 8:1. https://doi.org/10.4172/2155-9597.1000304

Scott JD, Pascoe EL, Sajid MS, Foley JE. (2020). Monitoring of Nesting Songbirds Detects Established Population of Blacklegged Ticks and Associated Lyme Disease Endemic Area in Canada. Healthcare. 8: 59. https://doi.org/10.3390/antibiotics8040269; PMid:31888310 PMCid:PMC6963229

Shor S, Green C, Szantyr B, Phillips S, Liegner K, Burrascano JJr, Bransfield R, Maloney EL. (2019). Chronic Lyme Disease: An Evidence-Based Definition by the ILADS Working Group. Antibiotics. 8: 269. https://doi.org/10.3390/antibiotics8040269; PMid:31888310 PMCid:PMC6963229

https://phc.org.ua/news/za-tri-misyaci-2020-go-roku-v-ukraini-zafiksovano-236-vipadkiv-khvorobi-layma.

https://medvestnik.ru/content/news/IDSA-AAN-ACR@razrabotali-rekomendacii-po-kleshevomu-borreliozu.html

https://kingwestmedical.ca/documents/CHEO-Lyme-Disease-July2018.pdf.

https://www.canada.ca/en/public-health/services/lyme-disease/risk-lyme-disease

Published

2020-09-28