Melatonin- and cortisol-producing function in children with chronic gastroduodenitis and primary arterial hypertension
Keywords:
chronicgastro duodenitis, arterial hypertension, combined pathology, melatonin, cortisolAbstract
Research aim: to characterize the exchange of melatonin and cortisol in children with concomitant chronic gastroduodenitis (CGD) and primary arterial hypertension (PAH).
Materials and methods. We examined 101 children aged 14 to 17 years. first group consisted of 30 children with a combination of CGD and PAH, the second group — 33 children with CGD and normal blood pressure (BP), the third group — 38 healthy children. The levels of «free» cortisol (FC) and 6-sulfatoxymelatonin (6-SOMT) were evaluated in daytime and nighttime urine.
Results. Compared with healthy children, the concentrations of FC and 6-SOMT during the day were higher in patients of both clinical groups. At night FC was higher in comparison with healthy children only in the first group (p<0.05). The nighttime level of 6-SOMT did not significantly differ from healthy children. However, in comparison with the second group, patients of the first group had a higher level of daytime FC (p=0.03) and a tendency to a decrease in nighttime excretion of 6-SOMT (p=0.05). The most pronounced circadian disorders of 6-SOMT and FC excretion were formed during erosive changes in the gastric mucosa and duodenum, especially when combined with PAH.
Conclusions. In children with combined course of PAH and CGD significantly changed in the urine indicators of 6-COMT and FC, than in healthy and patients with CGD. Such changes are more pronounced with erosive lesions of the gastric mucosa.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies.
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