Iron metabolism in children with bronchial asthma, depending on the presence or absence of disease control
Keywords:
asthma, children, serum iron, receptorsAbstract
Iron plays a significant role in the pathogenesis of bronchial asthma (BA). Iron-containing proteins (ferroproteins) are direct participants in the processes of transport and exchange of oxygen and carbon dioxide (hemoglobin, myoglobin), provide transport and deposition of iron (ferritin, transferrin, hemosiderin, siderchromes).The aim of the study. Determine changes in the parameters of iron metabolism in children with bronchial asthma, depending on the presence or absence of disease control.
Materials and methods. In accordance with the goal, we examined 144 children with asthma, aged 6 to 17 years. The definition of iron, total and latent iron binding ability of serum, saturation coefficient of transferrin, and the level of ferritin in serum carried out. The sTfR / log index was calculated using ferritin. The content of soluble receptor-to-transferrin (sTfR) in serum was determined.
Results. The conducted research revealed that in the examined children with asthma patients, there was a significant (p<0.01) increase in the total iron binding capacity of the serum in the group with a latent iron deficiency of 6.52% and 6.38% in the deficiency group iron in relation to healthy children. Depending on the level of the sTfR / log index of ferritin and severity of the disease, it has been established that in children with asthma with persistent severe trachea, latent iron deficiency was detected by 16% more often compared with the group of children of middle aged and 25% more often in comparable to a group of children of the lung.
Conclusions. In children with uncontrolled BA, latent iron deficiency was found to be three times more frequent than in children with controlled disease. This fact may indicate the depletion of tissue and transport form of iron in children with severe BA, and is the one of factors which exacerbate BA disease.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of a participating institution. The informed consent of the patient was obtained for conducting the studies.
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