Особливості клінічного перебігу алергодерматозів у дітей (огляд літератури)


  • O.M. Mochulska I. Horbachevsky Ternopil National Medical University of MHC of Ukraine, Ukraine
  • K.T. Hlushko I. Horbachevsky Ternopil National Medical University of MHC of Ukraine, Ukraine


children, allergy, allergic dermatoses, clinical criteria


The prevalence of allergic diseases is constantly growing around the world. According to WHO forecasts, most of the world's population will suffer from various allergies by 2050, at the same time any substance can be an allergen, and the XXI century will be the era of allergies. In the structure of allergic diseases in children the leading place is occupied by allergic skin lesions — allergic dermatoses, which are characterized by pronounced clinical polymorphism, acute or chronic stage with the development of concomitant pathological changes in many systems of the growing child's body. Allergic dermatoses are a large group of skin diseases, including: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions.

Purpose — to describe clinical criteria for the differential diagnosis of allergodermatoses in children in order to increase its effectiveness.

Conclusions. Allergodermatoses in children are characterized by polymorphism of clinical manifestations, which depends on the specific nosology. There is a tendency to increase the frequency of allergic skin diseases in children, especially severe forms with recurrent course, resistant to traditional pharmacotherapy. Comprehensive detailed study of clinical manifestations of allergic dermatoses in children will contribute to the development of differential diagnostic criteria for allergic dermatoses in children, to verify accurate diagnosis and to prescribe the pathogenesis-based treatment for various allergic skin diseases in time.



Akan A, Dibek-Misirlroglu E, Civelek E, Vezir E, Kocabas CN. (2020). Diagnosis of atopic dermatitis in children: comparison of the Hanifin-Rajka and the United Kingdom Working Party criteria. Allergologia et Immunopathologia. 48 (2): 175-181. URL: http://www.sciencedirect.com/science/article/pii/S0301054619301156. https://doi.org/10.1016/j.aller.2019.07.008; PMid:31611041

Beltrani VS. (1998). Allergic Dermatoses. Medical Clinics of North America. 82 (5): 1105-1133. URL: http://www.sciencedirect.com/science/article/pii/S0025712505704053. https://doi.org/10.1016/S0025-7125(05)70405-3

Bourrain JL. (2017). Toxicodermias. EMC - Dermatologia. 51 (4): 1-13. URL: http://www.sciencedirect.com/science/article/pii/S1761289617870527. https://doi.org/10.1016/S1761-2896(17)87052-7

Dowling PJ, Kader R, Portnoy JM. (2019). COLA (Conferences On-Line Allergy) at 10 Years - Evolution of an Online Fellowship Curriculum. The Journal of Allergy and Clinical Immunology: In Practice. 7 (8): 2568-2573. URL: http://www.sciencedirect.com/science/article/pii/S2213219819305975. https://doi.org/10.1016/j.jaip.2019.06.025; PMid:31279862

Fawbert K, Leech S. (2020). Recurrent urticaria and angioedema. Paediatrics and Child Health. 30 (7): 243-248. URL: http://www.sciencedirect.com/science/article/pii/S175172222030072X. https://doi.org/10.1016/j.paed.2020.04.001

Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI. (2017). Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States. Journal of the American Academy of Dermatology. 76 (5): 811-817. URL: http://www.sciencedirect.com/science/article/pii/S0190962216312853. https://doi.org/10.1016/j.jaad.2016.12.024; PMid:28285784 PMCid:PMC5502094

Millan GG, Lopez-Bran E. (2018). Toxicodermias. Medicine - Programa de Formacion Medica Continuada Acreditado. 12 (48): 2846-2853. URL: http://www.sciencedirect.com/science/article/pii/S0304541218300076. https://doi.org/10.1016/j.med.2018.01.007

Napolitano M, Fabbrocini G, Patruno C. (2019). Allergic contact dermatitis in patients with atopic dermatitis: A retrospective study. The Journal of Allergy and Clinical Immunology: In Practice. 7 (7): 2459-2461. URL: http://www.sciencedirect.com/science/article/pii/S2213219819303307. https://doi.org/10.1016/j.jaip.2019.03.045; PMid:30954642

Nassau S, Fonacier L. (2020). Allergic Contact Dermatitis. Medical Clinics of North America. 104 (1): 61-76. URL: http://www.sciencedirect.com/science/article/pii/S0025712519300884. https://doi.org/10.1016/j.mcna.2019.08.012; PMid:31757238

Nguyen V, Simon L, Jaqua E. (2016). Allergic Dermatoses. Primary Care: Clinics in Office Practice. 43 (3): 433-449. URL: http://www.sciencedirect.com/science/article/pii/S0095454316300239. https://doi.org/10.1016/j.pop.2016.04.011; PMid:27545733

Noe MH, Micheletti RG. (2020). Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis. Clinics in Dermatology. 6: 738-744. URL: http://www.sciencedirect.com/science/article/pii/S0738081X20301498. https://doi.org/10.1016/j.clindermatol.2020.06.016; PMid:33341195

Ozceker D, Haslak F, Dilek F, Sipahi S, Yucel E, Guler N, Tamay Z. (2019). Contact sensitization in children with atopic dermatitis. Allergologia et Immunopathologia. 47 (1): 47-51. URL: http://www.sciencedirect.com/science/article/pii/S0301054618301009. https://doi.org/10.1016/j.aller.2018.06.002; PMid:30193890